Phloroglucinol Derivatives Exert Anti‐Inflammatory Effects and Attenuate Cognitive Impairment in LPS‐Induced Mouse Model
Abstract: Neuroinflammation is an inflammatory immune response that arises in the central nervous system. It is one of the primary causes of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Phloroglucinol (PG) is a natural product contained in extracts of plant, algae and microbe and has been reported to have antioxidant and anti‐inflammatory properties. In this study, we synthesized PG derivatives to enhance antioxidant and anti‐inflammatory activity. Among PG derivatives, 6 a suppressed pro‐oxidative and inflammatory molecule nitric oxide (NO) production more effectively than PG. Moreover, 6 a dose‐dependently reduced the expression of proinflammatory cytokines such as IL‐6, IL‐1β, TNF‐α, and NO producing enzyme iNOS in lipopolysaccharide (LPS)‐stimulated BV‐2 microglial cells. Additionally, we confirmed that 6 a alleviated cognitive impairment and glial activation in mouse model of LPS‐induced neuroinflammation. These findings suggest that novel PG derivative, 6 a, is a potential treatment for neurodegenerative diseases.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Phloroglucinol Derivatives Exert Anti‐Inflammatory Effects and Attenuate Cognitive Impairment in LPS‐Induced Mouse Model ; day:04 ; month:07 ; year:2024 ; extent:12
ChemMedChem ; (04.07.2024) (gesamt 12)
- Creator
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Kim, Jushin
Won Choi, Ji
Jeong Kim, Hyeon
Kim, Byungeun
Kim, Yoowon
Hwejin Lee, Elijah
Kim, Rium
Kim, Jaehwan
Park, Jiwoo
Jeong, Yeeun
Park, Jong‐Hyun
Duk Park, Ki
- DOI
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10.1002/cmdc.202400056
- URN
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urn:nbn:de:101:1-2407081422244.170953777660
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:51 AM CEST
Data provider
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Associated
- Kim, Jushin
- Won Choi, Ji
- Jeong Kim, Hyeon
- Kim, Byungeun
- Kim, Yoowon
- Hwejin Lee, Elijah
- Kim, Rium
- Kim, Jaehwan
- Park, Jiwoo
- Jeong, Yeeun
- Park, Jong‐Hyun
- Duk Park, Ki
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