Zinc enhances the expression of morphine-induced conditioned place preference through dopaminergic and serotonergic systems
Abstract: The antidepressant-like effects of zinc (Zn) have been documented in some animal models of depression. In addition, antidepressants may reduce the abuse potential of opioids by affecting their rewarding effect. Hence, this study was performed to investigate the effect of Zn on the expression of morphine-induced conditioned place preference (CPP) in male rats. We used an unbiased CPP paradigm for investigating the effect of Zn. The intraperitoneal (i.p.) and intracerebroventricular (i.c.v.) administrations of Zn (5-20 mg/kg, i.p., and 10 nmol/rat, respectively) with or without morphine did not induce conditioned place aversion (CPA) or CPP during acquisition phase. However, the same i.p. and i.c.v. administrations of Zn induced morphine-like CPP in the expression phase. Pre-treatment with dopamine receptor antagonists (SCH23390, sulpiride, and haloperidol) and serotonin receptor antagonists (WAY100135, ketanserin, and ondansetron) reversed the enhancement effect of Zn on the expression of morphine-induced CPP (especially 20mg/kg, i.p. and 10 nmol/rat, i.c.v.). These findings suggest that acute i.p. and i.c.v administration of Zn might enhance the rewarding properties of morphine through involvement with dopaminergic and serotonergic neuronal systems.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Zinc enhances the expression of morphine-induced conditioned place preference through dopaminergic and serotonergic systems ; volume:10 ; number:1 ; year:2019 ; pages:51-61 ; extent:11
Biomolecular concepts ; 10, Heft 1 (2019), 51-61 (gesamt 11)
- Creator
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Mesbahzadeh, Behzad
Moradi-kor, Nasroallah
Abbasi-Maleki, Saeid
- DOI
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10.1515/bmc-2019-0006
- URN
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urn:nbn:de:101:1-2409241642423.234956715542
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:36 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Mesbahzadeh, Behzad
- Moradi-kor, Nasroallah
- Abbasi-Maleki, Saeid
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Dopaminergic and serotonergic modulation of working memory
Corticosterone after early adolescent stress prevents social avoidance, aversive behavior, and morphine-conditioned place preference in adulthood
Intact serotonergic and dopaminergic systems in two cases of orthostatic tremor
Differential regulation of amphetamine-induced serotonergic and dopaminergic efflux by syntaxin 1A
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Dopaminergic and serotonergic modulation of working memory
Corticosterone after early adolescent stress prevents social avoidance, aversive behavior, and morphine-conditioned place preference in adulthood
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The impact of serotonergic and dopaminergic genetic variation on endophenotypes of emotional processing
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