Catalytic Synthesis of β‐(Hetero) arylethylamines: Modern Strategies and Advances

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Abstract: β‐(Hetero) arylethylamines appear in a myriad of pharmaceuticals due to their broad spectrum of biological properties, making them prime candidates for drug discovery. Conventional methods for their preparation often require engineered substrates that limit the flexibility of the synthetic routes and the diversity of compounds that can be accessed. Consequently, methods that provide rapid and versatile access to those scaffolds remain limited. To overcome these challenges, synthetic chemists have designed innovative and modular strategies to access the β‐(hetero) arylethylamine motif, paving the way for their more extensive use in future pharmaceuticals. This review outlines recent progresses in the synthesis of (hetero) arylethylamines and emphasizes how these innovations have enabled new levels of molecular complexity, selectivity, and practicality.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Catalytic Synthesis of β‐(Hetero) arylethylamines: Modern Strategies and Advances ; day:31 ; month:08 ; year:2023 ; extent:27
Angewandte Chemie ; (31.08.2023) (gesamt 27)

Creator: Pozhydaiev, Valentyn
Muller, Cyprien
Moran, Joseph
Lebœuf, David

DOI: 10.1002/ange.202309289

URN: urn:nbn:de:101:1-2023090115100384522247

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:55 AM CEST

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Pozhydaiev, Valentyn
Muller, Cyprien
Moran, Joseph
Lebœuf, David

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