Impact of calcium propionate on cellular behavior in A549 and DMS114 lung cancer cell lines
Objectives: To investigate the cellular and apoptotic effects of food additive calcium propionate by in vitro methods. Methods: Cell viability by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, intracellular Glutathione (GSH) by luminometric method, mitochondrial membrane potential (MMP) by fluorometry, apoptosis by dual Acridine Orange/Ethidium Bromide (AO/EB) fluorescent staining were studied in lung cells. Results: It has been observed that calcium propionate reduced GSH and MMP levels significantly while increased cytotoxicity, apoptosis, and reactive oxygen species (ROS) levels in both A549 and DMS114 cancer cells in a dose-dependent manner. Conclusions: Cytotoxic effects of calcium propionate were more pronounced in cancer cells compared to healthy cells, suggesting its potential suitability as a chemo-preventive agent.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Impact of calcium propionate on cellular behavior in A549 and DMS114 lung cancer cell lines ; volume:49 ; number:5 ; year:2024 ; pages:666-673 ; extent:08
Turkish journal of biochemistry ; 49, Heft 5 (2024), 666-673 (gesamt 08)
- Urheber
-
Okyay, Tugba Muhlise
Güler, Eray Metin
Kale, Ebru
Gultekin, Fatih
Koldas, Macit
- DOI
-
10.1515/tjb-2024-0054
- URN
-
urn:nbn:de:101:1-2410241537200.324704492556
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:27 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Okyay, Tugba Muhlise
- Güler, Eray Metin
- Kale, Ebru
- Gultekin, Fatih
- Koldas, Macit
Ähnliche Objekte (12)
Thermal decomposition of calcium propionate: films and powders
Binding interaction studies of sodium benzoate, calcium propionate and sodium propionate with bovine serum albumin using spectroscopic method and molecular docking
Calcium-dependent release of adenosine and uridine nucleotides from A549 cells
Silica nanoparticles-induced cytotoxicity and genotoxicity in A549 cell lines
Calcium ion as cellular messenger
On the Substrate Scope of Dimethylsulfonium Propionate Lyases toward Dimethylsulfoxonium Propionate Derivatives
Strain-specific behavior of Mycobacterium tuberculosis in A549 lung cancer cell line
Biological behaviors and proteomics analysis of hybrid cell line EAhy926 and its parent cell line A549
Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549
Cellular calcium compartmentalisation and transport in biomineralisation
Distinct cellular states determine calcium signaling response
Downregulation of caveolin-1 affects bleomycin induced growth arrest and cellular senescence in A549 cells
Thermal decomposition of calcium propionate: films and powders
Binding interaction studies of sodium benzoate, calcium propionate and sodium propionate with bovine serum albumin using spectroscopic method and molecular docking
Calcium-dependent release of adenosine and uridine nucleotides from A549 cells
Silica nanoparticles-induced cytotoxicity and genotoxicity in A549 cell lines
Calcium ion as cellular messenger
On the Substrate Scope of Dimethylsulfonium Propionate Lyases toward Dimethylsulfoxonium Propionate Derivatives
Strain-specific behavior of Mycobacterium tuberculosis in A549 lung cancer cell line
Biological behaviors and proteomics analysis of hybrid cell line EAhy926 and its parent cell line A549
Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549
Cellular calcium compartmentalisation and transport in biomineralisation
Distinct cellular states determine calcium signaling response
Downregulation of caveolin-1 affects bleomycin induced growth arrest and cellular senescence in A549 cells
Thermal decomposition of calcium propionate: films and powders
Binding interaction studies of sodium benzoate, calcium propionate and sodium propionate with bovine serum albumin using spectroscopic method and molecular docking
Calcium-dependent release of adenosine and uridine nucleotides from A549 cells
Silica nanoparticles-induced cytotoxicity and genotoxicity in A549 cell lines
Calcium ion as cellular messenger
On the Substrate Scope of Dimethylsulfonium Propionate Lyases toward Dimethylsulfoxonium Propionate Derivatives
Strain-specific behavior of Mycobacterium tuberculosis in A549 lung cancer cell line
Biological behaviors and proteomics analysis of hybrid cell line EAhy926 and its parent cell line A549
Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549
Cellular calcium compartmentalisation and transport in biomineralisation
Distinct cellular states determine calcium signaling response