Ferroptosis Inducing Co (III) Polypyridine Sulfasalazine Complex for Therapeutically Enhanced Anticancer Therapy

Abstract: Despite significant improvements in the treatment of cancerous tumors in the last decades, cancer remains one of the deadliest diseases worldwide. To overcome the shortcomings of currently applied chemotherapeutic treatments, much research efforts have been devoted towards the development of ferroptosis inducing anticancer agents. Ferroptosis is a newly described form of regulated, non‐apoptotic cell death that is associated with high potential inside the clinics. Herein, the chemical synthesis and biological evaluation of a Co (III) polypyridine sulfasalazine complex as a ferroptosis inducer is reported. Upon entering the cancerous cells, the metal complex primarily accumulated in the mitochondria, triggering the production of hydroxy radicals and lipid peroxides, ultimately causing cell death by ferroptosis. The compound demonstrated to eradicate various monolayer cancer cells as well as colon carcinoma multicellular tumor spheroids. To the best of our knowledge this study reports on the first example of a Co (III) complex that is capable of inducing ferroptosis.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Ferroptosis Inducing Co (III) Polypyridine Sulfasalazine Complex for Therapeutically Enhanced Anticancer Therapy ; day:30 ; month:10 ; year:2024 ; extent:10
Angewandte Chemie / International edition. International edition ; (30.10.2024) (gesamt 10)

Urheber
Montesdeoca, Nicolás
Johannknecht, Lukas
Efanova, Elizaveta
Heinen‐Weiler, Jacqueline
Karges, Johannes

DOI
10.1002/anie.202412585
URN
urn:nbn:de:101:1-2410301404116.842199518992
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:36 MESZ

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Beteiligte

  • Montesdeoca, Nicolás
  • Johannknecht, Lukas
  • Efanova, Elizaveta
  • Heinen‐Weiler, Jacqueline
  • Karges, Johannes

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