EUS-guided hydrogel injection to separate pancreatic head carcinoma from duodenum for enhanced radiotherapy: multi-site feasibility study

Background and study aims: The proximity of a pancreas head tumor to the duodenum often limits delivery of an ablative dose of radiation therapy. This study evaluated the feasibility and safety of using an injectable polyethylene glycol (PEG) hydrogel between the head of the pancreas and duodenum. Patients and methods: In a multi-site feasibility cohort study of patients with localized pancreatic cancer, PEG hydrogel was injected under endoscopic ultrasound guidance to temporarily position the duodenum away from the pancreas. Procedure characteristics were recorded, including hydrogel volume and space created. Patients were monitored for adverse events (AEs) and radiotherapy toxicity. Results: In all six intent-to-treat patients (four with borderline resectable, two with locally advanced disease), the ability to place and visualize PEG hydrogel and create space between the duodenum and head of pancreas was successful. There were no procedure-related AEs resulting in radiotherapy delay. There were no device-related AEs and no reports of pancreatitis. Conclusions: PEG hydrogel was successfully placed, created space between the duodenum and the head of the pancreas, and was not associated with major toxicity. Enhancing radiotherapy for pancreatic cancer by using PEG hydrogel to create peri-duodenal space could have beneficial implications for treatment and warrants more exploration.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: EUS-guided hydrogel injection to separate pancreatic head carcinoma from duodenum for enhanced radiotherapy: multi-site feasibility study ; day:25 ; month:03 ; year:2024 ; Endoscopy International Open ; (25.03.2024)

Contributors, Places and Time

• Contributor: Bhutani, Manoop ; Narang, Amol ; Ding, Kai ; Casey, Brenna W. ; Krishnan, Kumar ; Koay, Eugene ; Hong, Theodore S. ; Herman, Joseph ; Griffin, Kristen ; Shin, Eun Ji

Further information

• DOI: 10.1055/a-2286-1995
• URN: urn:nbn:de:101:1-2405091141470.736668320601
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:49 AM CEST