BCG induced necrosis of the entire bladder urothelium

Abstract: Instillation therapy with attenuated tuberculosis bacteria (BCG) can significantly reduce rates of recurrence of non-muscle invasive bladder cancer. Local and systemic side effects such as dysuria, irritative voiding symptoms or partial bladder contracture and systemic inflammation were reported. A 75 year-old male patient with recurrent non muscle invasive bladder cancer developed necrosis of the entire bladder urothelium more than six years after BCG instillation immunotherapy. The resulting irritative voiding symptoms and low bladder capacity required radical cystectomy. BCG instillation can cause severe side effects, which develop gradually and eventually need radical surgical therapy such as cystectomy without tumor recurrence

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch
Notes
Urology case reports. - 3, 5 (2015) , 161-163, ISSN: 2214-4420

Event
Veröffentlichung
(where)
Freiburg
(who)
Universität
(when)
2019

DOI
10.1016/j.eucr.2015.06.002
URN
urn:nbn:de:bsz:25-freidok-1296015
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
25.03.2025, 1:46 PM CET

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Time of origin

  • 2019

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