Switching Chemoselectivity: Using Mechanochemistry to Alter Reaction Kinetics

Abstract: A reaction manifold has been discovered in which the chemoselectivity can be altered by switching between neat milling and liquid assisted grinding (LAG) with polar additives. After investigation of the reaction mechanism, it has been established that this switching in reaction pathway is due to the neat mechanochemical conditions exhibiting different kinetics for a key step in the transformation. This proof of concept study demonstrates that mechanochemistry can be used to trap the kinetic product of a reaction. It is envisaged that, if this concept can be successfully applied to other transformations, novel synthetic processes could be discovered and known reaction pathways perturbed or diverted.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Switching Chemoselectivity: Using Mechanochemistry to Alter Reaction Kinetics ; volume:57 ; number:49 ; year:2018 ; pages:16104-16108 ; extent:5 ; Angewandte Chemie / International edition. International edition ; 57, Heft 49 (2018), 16104-16108 (gesamt 5)

Contributors, Places and Time

• Creator: Howard, Joseph L. ; Brand, Michael C. ; Browne, Duncan L.

Further information

• DOI: 10.1002/anie.201810141
• URN: urn:nbn:de:101:1-2022082607112805564158
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:27 AM CEST