A 14-year-old girl with premature ovarian insufficiency but with a positive pregnancy test

Objectives: Childhood cancer survivors are at risk for premature ovarian insufficiency, especially after treatment with alkylating agents. The objective of this report is to highlight a case in which this phenomenon caused a false-positive pregnancy test. Case presentation: A workup was performed in a 14-year-old girl with a positive pregnancy test. She was diagnosed with stage IV neuroblastoma of the left adrenal gland at the age of 4 years. She received extensive treatment, including alkylating agents, and had been diagnosed with premature ovarian insufficiency. An LH/hCG suppression test was performed using high dose 17 bèta-estradiol: hCG levels normalized. Conclusions: The pregnancy test was false-positive due to production of low amounts of hCG by the pituitary gland as a result of high LH concentrations following premature ovarian insufficiency. It may be helpful to perform the LH/hCG suppression test to prove pituitary origin of the hCG overproduction.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: A 14-year-old girl with premature ovarian insufficiency but with a positive pregnancy test ; volume:37 ; number:5 ; year:2024 ; pages:482-485 ; extent:04 ; The journal of pediatric endocrinology and metabolism ; 37, Heft 5 (2024), 482-485 (gesamt 04)

Beteiligte, Orts- und Zeitangaben

• Urheber: Touwslager, Robbert N.H. ; Zwaan, C. Michel ; Bakker, Boudewijn ; Lentjes, Eef G.W.M. ; Looijenga, Leendert H.J. ; van Santen, Hanneke M.

Weitere Informationen

• DOI: 10.1515/jpem-2024-0019
• URN: urn:nbn:de:101:1-2405041601257.083141229802
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:55 MESZ