Mediator structure and function in transcription initiation
Abstract: Recent advances in cryo-electron microscopy have led to multiple structures of Mediator in complex with the RNA polymerase II (Pol II) transcription initiation machinery. As a result we now hold in hands near-complete structures of both yeast and human Mediator complexes and have a better understanding of their interactions with the Pol II pre-initiation complex (PIC). Herein, we provide a summary of recent achievements and discuss their implications for future studies of Mediator and its role in gene regulation.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Mediator structure and function in transcription initiation ; volume:404 ; number:8-9 ; year:2023 ; pages:829-837 ; extent:09
Biological chemistry ; 404, Heft 8-9 (2023), 829-837 (gesamt 09)
- Creator
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Rengachari, Srinivasan
Schilbach, Sandra
Cramer, Patrick
- DOI
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10.1515/hsz-2023-0158
- URN
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urn:nbn:de:101:1-2023090714210757251925
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:59 AM CEST
Data provider
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Rengachari, Srinivasan
- Schilbach, Sandra
- Cramer, Patrick
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Structure of the closed Pol II transcription initiation complex and implications for promoter opening
Conserved architecture of the core RNA polymerase II transcription initiation complex and an integrative model of Ctk3
Role of the RNA polymerase II C-terminal domain in transcription termination and function of Spt5 in 3' RNA-processing factor recruitment
RNA polymerase I structure and transcription regulation
Crystal structure of Core Factor and its use to analyze RNA polymerase I initiation
Genomic data integration with hidden Markov models to understand transcription regulation
Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex
Genome-wide occupancy profiling of the RNA polymerase II transcription machinery in S. cerevisiae
Structure and function of RNA Polymerase II-Bye1 complexes
Integrative structural and functional studies of Mediator and RNA polymerase II transcription initiation assemblies
Structural basis of human mitochondrial transcription initiation and processive elongation
RNA polymerase I complex structures elucidate mechanisms of transcription initiation and elongation
Structure of the closed Pol II transcription initiation complex and implications for promoter opening
Conserved architecture of the core RNA polymerase II transcription initiation complex and an integrative model of Ctk3
Role of the RNA polymerase II C-terminal domain in transcription termination and function of Spt5 in 3' RNA-processing factor recruitment
RNA polymerase I structure and transcription regulation
Crystal structure of Core Factor and its use to analyze RNA polymerase I initiation
Genomic data integration with hidden Markov models to understand transcription regulation
Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex
Genome-wide occupancy profiling of the RNA polymerase II transcription machinery in S. cerevisiae