Mediator structure and function in transcription initiation
Abstract: Recent advances in cryo-electron microscopy have led to multiple structures of Mediator in complex with the RNA polymerase II (Pol II) transcription initiation machinery. As a result we now hold in hands near-complete structures of both yeast and human Mediator complexes and have a better understanding of their interactions with the Pol II pre-initiation complex (PIC). Herein, we provide a summary of recent achievements and discuss their implications for future studies of Mediator and its role in gene regulation.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Mediator structure and function in transcription initiation ; volume:404 ; number:8-9 ; year:2023 ; pages:829-837 ; extent:09
Biological chemistry ; 404, Heft 8-9 (2023), 829-837 (gesamt 09)
- Urheber
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Rengachari, Srinivasan
Schilbach, Sandra
Cramer, Patrick
- DOI
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10.1515/hsz-2023-0158
- URN
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urn:nbn:de:101:1-2023090714210757251925
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:59 MESZ
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Beteiligte
- Rengachari, Srinivasan
- Schilbach, Sandra
- Cramer, Patrick
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