Factor VIII prophylactic therapy reduces neurological complications in patients with Hemophilia A

Abstract: Background: Bleeding in hemophiliacs can cause complications in the central and peripheral nervous system (CNS and PNS). The incidence of intracranial hemorrhage has reduced after the introduction of prophylactic treatment with factor VIII or IX, but the benefits of this therapy have not yet been evaluated on PNS complications. Objective: The aim of this study was to determine the prevalence of neurological complications in hemophiliacs and verify the effect of prophylactic therapy in these patients, including PNS disorders. Methods: We retrospectively evaluated the prevalence of CNS and PNS disorders caused by bleeding in hemophiliacs seen at the Hemocentro Regional Norte, Ceará, Brazil, from 1992 to 2018, and we compared the incidence in different periods (before and after the introduction of prophylactic treatment in 2011). Results: Of 75 hemophilia A patients evaluated (4.61/100.000 population), 13.3% (n=10) had either CNS (n=5) or PNS (n=5) disorders secondary to bleeding. Patients submitted to factor VIII replacement prophylactic therapy were less likely to have CNS events: from 1992 to 2011, 5 of 63 patients had CNS disease, while from 2011 to 2018, there were no new cases (p=0.0181). From 2011 to 2018, 5 PNS events occurred in patients without prophylactic therapy, whereas none occurred in those covered by prophylactic therapy (5/20 versus 0/29, p=0.0081). Conclusions: The prevalence of neurological complications in hemophiliacs in our cohort is similar to other studies. Similar to CNS, prophylactic therapy also reduces the risk of PNS complications. This is the first report in the literature showing this benefit.

Angaben zum Objekt

• Weitere Titel: Terapia profilática com Fator VIII reduz complicações neurológicas em paciente com Hemofilia A
• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Factor VIII prophylactic therapy reduces neurological complications in patients with Hemophilia A ; volume:79 ; number:12 ; year:2021 ; pages:1116-1112 ; Arquivos de neuro-psiquiatria ; 79, Heft 12 (2021), 1116-1112

Beteiligte, Orts- und Zeitangaben

• Beteiligte Personen und Organisationen: FERNANDES, José Marcelino Aragão ; GONDIM, Francisco de Assis Aquino ; DIAS, Antônia Maria Negreiro ; RIBEIRO, Rosângela de Albuquerque ; FERREIRA, Luiz Ivando Pires ; PINTO, Vicente de Paulo Teixeira

Weitere Informationen

• DOI: 10.1590/0004-282X-ANP-2020-0467
• URN: urn:nbn:de:101:1-2023072012233784516010
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:54 MESZ