PLA and PBAT‐Based Electrospun Fibers Functionalized with Antibacterial Bio‐Based Polymers

Abstract: Antimicrobial fibers based on biodegradable polymers, poly (lactic acid) (PLA), and poly (butylene adipate‐co‐terephthalate) (PBAT) are prepared by electrospinning. For this purpose, a biodegradable/bio‐based polyitaconate containing azoles groups (PTTI) is incorporated at 10 wt.% into the electrospinning formulations. The resulting fibers functionalized with azole moieties are uniform and free of beads. Then, the accessible azole groups are subjected to N‐alkylation, treatment that provides cationic azolium groups with antibacterial activity at the surface of fibers. The positive charge density, roughness, and wettability of the cationic fibers are evaluated and compared with flat films. It is confirmed that these parameters exert an important effect on the antimicrobial properties, as well as the length of the alkylating agent and the hydrophobicity of the matrix. The quaternized PLA/PTTI fibers exhibit the highest efficiency against the tested bacteria, yielding a 4‐Log reduction against S. aureus and 1.7‐Log against MRSA. Then, biocompatibility and bioactivity of the fibers are evaluated in terms of adhesion, morphology and viability of fibroblasts. The results show no cytotoxic effect of the samples, however, a cytostatic effect is appreciated, which is ascribed to the strong electrostatic interactions between the positive charge at the fiber surface and the negative charge of the cell membranes.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: PLA and PBAT‐Based Electrospun Fibers Functionalized with Antibacterial Bio‐Based Polymers ; day:08 ; month:12 ; year:2022 ; extent:9 ; Macromolecular bioscience ; (08.12.2022) (gesamt 9)

Contributors, Places and Time

• Creator: Chiloeches, A. ; Fernández‐García, R. ; Fernández‐García, M. ; Mariano, A. ; Bigioni, I. ; Scotto d'Abusco, A. ; Echeverría, C. ; Muñoz‐Bonilla, A.

Further information

• DOI: 10.1002/mabi.202200401
• URN: urn:nbn:de:101:1-2022120914152274843783
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:30 AM CEST