Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages
Abstract: Derivatives of 4‐aminomethyl‐l‐phenylalanine with aromatic oligoamide foldamers as sidechain appendages were successfully charged on tRNA by means of flexizymes. Their subsequent incorporation both at the C‐terminus of, and within, peptide sequences by the ribosome, was demonstrated. These results expand the registry of chemical structures tolerated by the ribosome to sidechains significantly larger and more structurally defined than previously demonstrated.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages ; volume:59 ; number:12 ; year:2020 ; pages:4860-4864 ; extent:5
Angewandte Chemie / International edition. International edition ; 59, Heft 12 (2020), 4860-4864 (gesamt 5)
- Urheber
- DOI
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10.1002/anie.201914654
- URN
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urn:nbn:de:101:1-2022061314052255273019
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:24 MESZ
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Beteiligte
- Tsiamantas, Christos
- Kwon, Sunbum
- Rogers, Joseph M.
- Douat, Céline
- Huc, Ivan
- Suga, Hiroaki
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