Tonsillar Microbiome‐Derived Lantibiotics Induce Structural Changes of IL‐6 and IL‐21 Receptors and Modulate Host Immunity
Abstract: Emerging evidence emphasizes the functional impacts of host microbiome on the etiopathogenesis of autoimmune diseases, including rheumatoid arthritis (RA). However, there are limited mechanistic insights into the contribution of microbial biomolecules especially microbial peptides toward modulating immune homeostasis. Here, by mining the metagenomics data of tonsillar microbiome, a deficiency of the encoding genes of lantibiotic peptides salivaricins in RA patients is identified, which shows strong correlation with circulating immune cells. Evidence is provided that the salivaricins exert immunomodulatory effects in inhibiting T follicular helper (Tfh) cell differentiation and interleukin‐21 (IL‐21) production. Mechanically, salivaricins directly bind to and induce conformational changes of IL‐6 and IL‐21 receptors, thereby inhibiting the bindings of IL‐6 and IL‐21 to their receptors and suppressing the downstream signaling pathway. Finally, salivaricin administration exerts both prophylactic and therapeutic effects against experimental arthritis in a murine model of RA. Together, these results provide a mechanism link of microbial peptides‐mediated immunomodulation.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Tonsillar Microbiome‐Derived Lantibiotics Induce Structural Changes of IL‐6 and IL‐21 Receptors and Modulate Host Immunity ; day:28 ; month:08 ; year:2022 ; extent:15
Advanced science ; (28.08.2022) (gesamt 15)
- Creator
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Li, Jing
Jin, Jiayang
Li, Shenghui
Zhong, Yan
Jin, Yuebo
Zhang, Xuan
Xia, Binbin
Zhu, Yinhua
Guo, Ruochun
Sun, Xiaolin
Guo, Jianping
Hu, Fanlei
Xiao, Wenjing
Huang, Fei
Ye, Hua
Li, Ru
Zhou, Yunshan
Xiang, Xiaohong
Yao, Haihong
Yan, Qiulong
Su, Li
Wu, Lijun
Luo, Tuoping
Liu, Yudong
Guo, Xiaohuan
Qin, Junjie
Qi, Hai
He, Jing
Wang, Jun
Li, Zhanguo
- DOI
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10.1002/advs.202202706
- URN
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urn:nbn:de:101:1-2022083015294033136461
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:30 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Li, Jing
- Jin, Jiayang
- Li, Shenghui
- Zhong, Yan
- Jin, Yuebo
- Zhang, Xuan
- Xia, Binbin
- Zhu, Yinhua
- Guo, Ruochun
- Sun, Xiaolin
- Guo, Jianping
- Hu, Fanlei
- Xiao, Wenjing
- Huang, Fei
- Ye, Hua
- Li, Ru
- Zhou, Yunshan
- Xiang, Xiaohong
- Yao, Haihong
- Yan, Qiulong
- Su, Li
- Wu, Lijun
- Luo, Tuoping
- Liu, Yudong
- Guo, Xiaohuan
- Qin, Junjie
- Qi, Hai
- He, Jing
- Wang, Jun
- Li, Zhanguo
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