Integrative network-based analysis of magnetic resonance spectroscopy and genome wide expression in glioblastoma multiforme

Abstract: The goal of this study was to identify correlations between metabolites from proton MR spectroscopy and genetic pathway activity in glioblastoma multiforme (GBM). Twenty patients with primary GBM were analysed by short echo-time chemical shift imaging and genome-wide expression analyses. Weighed Gene Co-Expression Analysis was used for an integrative analysis of imaging and genetic data. N-acetylaspartate, normalised to the contralateral healthy side (nNAA), was significantly correlated to oligodendrocytic and neural development. For normalised creatine (nCr), a group with low nCr was linked to the mesenchymal subtype, while high nCr could be assigned to the proneural subtype. Moreover, clustering of normalised glutamine and glutamate (nGlx) revealed two groups, one with high nGlx being attributed to the neural subtype, and one with low nGlx associated with the classical subtype. Hence, the metabolites nNAA, nCr, and nGlx correlate with a specific gene expression pattern reflecting the previously described subtypes of GBM. Moreover high nNAA was associated with better clinical prognosis, whereas patients with lower nNAA revealed a shorter progression-free survival (PFS)

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Scientific Reports. 6 (2016), 29052, DOI 10.1038/srep29052, issn: 2045-2322 ; IN COPYRIGHT http://rightsstatements.org/page/InC/1.0 rs

Classification and Topics

• Keyword: Krebs ; Onkologie

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2016
• Creator: Heiland, Dieter Henrik ; Mader, Irina ; Schlosser, Pascal ; Pfeifer, Dietmar ; Carro, Maria Stella ; Lange, Thomas ; Schwarzwald, Ralf ; Vasilikos, Ioannis ; Urbach, Horst ; Weyerbrock, Astrid
• Contributor: Klinik für Neurochirurgie ; Medizinische Fakultät ; Institut für Medizinische Biometrie und Statistik ; Klinik für Neuroradiologie ; Albert-Ludwigs-Universität Freiburg

Further information

• DOI: 10.1038/srep29052
• URN: urn:nbn:de:bsz:25-freidok-121702
• Rights: Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:53 AM CEST