One-pot synthesis of new triazole-sucrose derivatives via click chemistry and evaluation of their antitubercular activity
Abstract: Readily prepared copper nanoparticles are an effective catalyst for 1,3-dipolar cycloaddition of carbohydrate azide and a variety of alkynes that furnishes the corresponding 1,2,3-triazole-sucrose derivatives in excellent yields. Products were screened for their antimycobacterial activity against Mycobacterium tuberculosisH37Rv strain. Two compounds, 3b,c, demonstrate significant growth inhibitory activity against the bacterial strain with a MIC of 3.125 mg/mL. The presence of an amide group on the 1,2,3-triazole ring enhances the inhibition activity of the molecules. The active compounds are not toxic to a normal cell line which signifies the lack of general cellular toxicity of these compounds.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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One-pot synthesis of new triazole-sucrose derivatives via click chemistry and evaluation of their antitubercular activity ; volume:22 ; number:4 ; year:2016 ; pages:239-242 ; extent:4
Heterocyclic communications ; 22, Heft 4 (2016), 239-242 (gesamt 4)
- Creator
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Hajlaoui, Khaoula
Guesmi, Ahlem
Ben Hamadi, Naoufel
Msaddek, Moncef
- DOI
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10.1515/hc-2016-0028
- URN
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urn:nbn:de:101:1-2501140236117.339969534310
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:29 AM CEST
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Associated
- Hajlaoui, Khaoula
- Guesmi, Ahlem
- Ben Hamadi, Naoufel
- Msaddek, Moncef
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