The role of Down syndrome cell adhesion molecule in Down syndrome
Abstract: Down syndrome (DS) is caused by the presence of an extra copy of the entire or a portion of human chromosome 21 (HSA21). This genomic alteration leads to elevated expression of numerous HSA21 genes, resulting in a variety of health issues in individuals with DS. Among the genes located in the DS “critical region” of HSA21, Down syndrome cell adhesion molecule (DSCAM) plays an important role in neuronal development. There is a growing body of evidence underscoring DSCAM’s involvement in various DS-related disorders. This review aims to provide a concise overview of the established functions of DSCAM, with a particular focus on its implications in DS. We delve into the roles that DSCAM plays in DS-associated diseases. In the concluding section of this review, we explore prospective avenues for future research to further unravel DSCAM’s role in DS and opportunities for therapeutic treatments.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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The role of Down syndrome cell adhesion molecule in Down syndrome ; volume:4 ; number:1 ; year:2024 ; pages:31-41 ; extent:011
Medical Review ; 4, Heft 1 (2024), 31-41 (gesamt 011)
- Urheber
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Hergenreder, Ty
Yang, Tao
Ye, Bing
- DOI
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10.1515/mr-2023-0056
- URN
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urn:nbn:de:101:1-2024032114380570673884
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 11:00 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Hergenreder, Ty
- Yang, Tao
- Ye, Bing
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