BOB.1/OBF.1 is required during B‐cell ontogeny for B‐cell differentiation and germinal center function
Abstract: BOB.1/OBF.1 is a lymphocyte‐specific transcriptional co‐activator of octamer‐dependent transcription. It regulates the expression of genes important for lymphocyte physiology together with the Oct‐1 and Oct‐2 transcription factors. So far, BOB.1/OBF.1 has been studied in conventional knockout mice, whereby a function of BOB.1/OBF.1 in B but also in T cells was described. The main characteristic of BOB.1/OBF.1‐deficient mice is the complete absence of germinal centers. However, it is entirely unsolved at which stage of B‐cell development BOB.1/OBF.1 expression is essential for germinal center formation. Still, it is not known whether defects observed late in B‐cell development of BOB.1/OBF.1‐deficient mice are merely a consequence of defective early B‐cell development. To answer the question, whether BOB.1/OBF.1 expression is required before or during the process of germinal center formation, we established a mouse system, which allows the conditional deletion of BOB.1/OBF.1 at different stages of B‐cell development. Our data reveal a requirement for BOB.1/OBF.1 during both early antigen‐independent and late antigen‐dependent B‐cell development, and further a requirement for efficient germinal center reaction during complete B‐cell ontogeny. By specifically deleting BOB.1/OBF.1 in germinal center B cells, we provide evidence that the failure to form germinal centers is a germinal center B‐cell intrinsic defect and not exclusively a consequence of defective early B‐cell maturation.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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BOB.1/OBF.1 is required during B‐cell ontogeny for B‐cell differentiation and germinal center function ; day:17 ; month:12 ; year:2021 ; extent:14
European journal of immunology ; (17.12.2021) (gesamt 14)
- Urheber
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Betzler, Annika C.
Fiedler, Katja
Hoffmann, Thomas K.
Fehling, Hans Joerg
Wirth, Thomas
Brunner, Cornelia
- DOI
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10.1002/eji.202149333
- URN
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urn:nbn:de:101:1-2021121714291479945388
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:26 MESZ
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Beteiligte
- Betzler, Annika C.
- Fiedler, Katja
- Hoffmann, Thomas K.
- Fehling, Hans Joerg
- Wirth, Thomas
- Brunner, Cornelia
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