Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- ISSN
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1750-1326
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
-
online resource.
- Erschienen in
-
Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency ; volume:15 ; number:1 ; day:16 ; month:3 ; year:2020 ; pages:1-19 ; date:12.2020
Molecular neurodegeneration ; 15, Heft 1 (16.3.2020), 1-19, 12.2020
- Urheber
-
Frew, Jonathan
Baradaran-Heravi, Alireza
Balgi, Aruna D.
Wu, Xiujuan
Yan, Tyler D.
Arns, Steve
Shidmoossavee, Fahimeh S.
Tan, Jason
Jaquith, James B.
Jansen-West, Karen R.
Lynn, Francis C.
Gao, Fen-Biao
Petrucelli, Leonard
Feldman, Howard H.
Mackenzie, Ian R.
Roberge, Michel
Nygaard, Haakon B.
- Beteiligte Personen und Organisationen
-
SpringerLink (Online service)
- DOI
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10.1186/s13024-020-00369-5
- URN
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urn:nbn:de:101:1-2020052918355301555769
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
14.08.2025, 10:50 MESZ
Datenpartner
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Beteiligte
- Frew, Jonathan
- Baradaran-Heravi, Alireza
- Balgi, Aruna D.
- Wu, Xiujuan
- Yan, Tyler D.
- Arns, Steve
- Shidmoossavee, Fahimeh S.
- Tan, Jason
- Jaquith, James B.
- Jansen-West, Karen R.
- Lynn, Francis C.
- Gao, Fen-Biao
- Petrucelli, Leonard
- Feldman, Howard H.
- Mackenzie, Ian R.
- Roberge, Michel
- Nygaard, Haakon B.
- SpringerLink (Online service)
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Lysosomal dysfunction and microglial hyperactivation in models of progranulin deficiency
Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice
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Loss of TMEM 106B potentiates lysosomal and FTLD ‐like pathology in progranulin‐deficient mice