Metagenomic Insight into The Global Dissemination of The Antibiotic Resistome
Abstract: The global crisis in antimicrobial resistance continues to grow. Estimating the risks of antibiotic resistance transmission across habitats is hindered by the lack of data on mobility and habitat‐specificity. Metagenomic samples of 6092 are analyzed to delineate the unique core resistomes from human feces and seven other habitats. This is found that most resistance genes (≈85%) are transmitted between external habitats and human feces. This suggests that human feces are broadly representative of the global resistome and are potentially a hub for accumulating and disseminating resistance genes. The analysis found that resistance genes with ancient horizontal gene transfer (HGT) events have a higher efficiency of transfer across habitats, suggesting that HGT may be the main driver for forming unique but partly shared resistomes in all habitats. Importantly, the human fecal resistome is historically different and influenced by HGT and age. The most important routes of cross‐transmission of resistance are from the atmosphere, buildings, and animals to humans. These habitats should receive more attention for future prevention of antimicrobial resistance. The study will disentangle transmission routes of resistance genes between humans and other habitats in a One Health framework and can identify strategies for controlling the ongoing dissemination and antibiotic resistance.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Metagenomic Insight into The Global Dissemination of The Antibiotic Resistome ; day:23 ; month:10 ; year:2023 ; extent:11
Advanced science ; (23.10.2023) (gesamt 11)
- Creator
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Zhang, Qi
Xu, Nuohan
Lei, Chaotang
Chen, Bingfeng
Wang, Tingzhang
Ma, Yunting
Lu, Tao
Penuelas, Josep
Gillings, Michael
Zhu, Yong‐Guan
Fu, Zhengwei
Qian, Haifeng
- DOI
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10.1002/advs.202303925
- URN
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urn:nbn:de:101:1-2023102315220622299494
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:49 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Zhang, Qi
- Xu, Nuohan
- Lei, Chaotang
- Chen, Bingfeng
- Wang, Tingzhang
- Ma, Yunting
- Lu, Tao
- Penuelas, Josep
- Gillings, Michael
- Zhu, Yong‐Guan
- Fu, Zhengwei
- Qian, Haifeng
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