Interferon‐mediated repression of miR ‐324‐5p potentiates necroptosis to facilitate antiviral defense

to related objects

Abstract: Mixed lineage kinase domain‐like protein (MLKL) is the terminal effector of necroptosis, a form of regulated necrosis. Optimal activation of necroptosis, which eliminates infected cells, is critical for antiviral host defense. MicroRNAs (miRNAs) regulate the expression of genes involved in various biological and pathological processes. However, the roles of miRNAs in necroptosis‐associated host defense remain largely unknown. We screened a library of miRNAs and identified miR‐324‐5p as the most effective suppressor of necroptosis. MiR‐324‐5p downregulates human MLKL expression by specifically targeting the 3′UTR in a seed region‐independent manner. In response to interferons (IFNs), miR‐324‐5p is downregulated via the JAK/STAT signaling pathway, which removes the posttranscriptional suppression of MLKL mRNA and facilitates the activation of necroptosis. In influenza A virus (IAV)‐infected human primary macrophages, IFNs are induced, leading to the downregulation of miR‐324‐5p. MiR‐324‐5p overexpression attenuates IAV‐associated necroptosis and enhances viral replication, whereas deletion of miR‐324‐5p potentiates necroptosis and suppresses viral replication. Hence, miR‐324‐5p negatively regulates necroptosis by manipulating MLKL expression, and its downregulation by IFNs orchestrates optimal activation of necroptosis in host antiviral defense.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Interferon‐mediated repression of miR ‐324‐5p potentiates necroptosis to facilitate antiviral defense ; day:23 ; month:06 ; year:2022 ; extent:19
EMBO reports / European Molecular Biology Organization ; (23.06.2022) (gesamt 19)

Creator: Dou, Xiaoyan
Yu, Xiaoliang
Du, Shujing
Han, Yu
Li, Liang
Zhang, Haoran
Yao, Ying
Du, Yayun
Wang, Xinhui
Li, Jingjing
Yang, Tao
Zhang, Wei
Yang, Chengkui
Ma, Feng
He, Sudan

DOI: 10.15252/embr.202154438

URN: urn:nbn:de:101:1-2022062315242347179878

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:20 AM CEST

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.

Show original at data provider

Associated

Dou, Xiaoyan
Yu, Xiaoliang
Du, Shujing
Han, Yu
Li, Liang
Zhang, Haoran
Yao, Ying
Du, Yayun
Wang, Xinhui
Li, Jingjing
Yang, Tao
Zhang, Wei
Yang, Chengkui
Ma, Feng
He, Sudan

Other Objects (12)

Structural model of intelligence beliefs, motivational beliefs, academic self-handicapping and academic adjustment in Chinese undergraduate students

Numb family proteins: novel players in cardiac morphogenesis and cardiac progenitor cell differentiation

Normalized solutions to a class of (2, q)-Laplacian equations

Enhancing throughput using channel access priorities in frequency hopping network using federated learning

Retraction Note: Enhancing throughput using channel access priorities in frequency hopping network using federated learning

Artikel

The costs of socializing with government officials: A new measure of corporate political connections

A one-year longitudinal study on the mediating role of problematic TikTok use and gender differences in the association between academic stress and academic procrastination

The role of Down syndrome cell adhesion molecule in Down syndrome

Functional insights into the role of a bacterial virulence factor and a host factor in Neisseria gonorrhoeae infection

A global compactness result with applications to a Hardy-Sobolev critical elliptic system involving coupled perturbation terms

Progress and Promise of Nitric Oxide‐Releasing Platforms

A novel approach to fuzzy soft sets in decision making based on grey relational analysis and MYCIN certainty factor

Structural model of intelligence beliefs, motivational beliefs, academic self-handicapping and academic adjustment in Chinese undergraduate students

Numb family proteins: novel players in cardiac morphogenesis and cardiac progenitor cell differentiation

Normalized solutions to a class of (2, q)-Laplacian equations

Enhancing throughput using channel access priorities in frequency hopping network using federated learning

Retraction Note: Enhancing throughput using channel access priorities in frequency hopping network using federated learning

Artikel

The costs of socializing with government officials: A new measure of corporate political connections

A one-year longitudinal study on the mediating role of problematic TikTok use and gender differences in the association between academic stress and academic procrastination

The role of Down syndrome cell adhesion molecule in Down syndrome

Functional insights into the role of a bacterial virulence factor and a host factor in Neisseria gonorrhoeae infection

A global compactness result with applications to a Hardy-Sobolev critical elliptic system involving coupled perturbation terms

Progress and Promise of Nitric Oxide‐Releasing Platforms

A novel approach to fuzzy soft sets in decision making based on grey relational analysis and MYCIN certainty factor

Structural model of intelligence beliefs, motivational beliefs, academic self-handicapping and academic adjustment in Chinese undergraduate students

Numb family proteins: novel players in cardiac morphogenesis and cardiac progenitor cell differentiation

Normalized solutions to a class of (2, q)-Laplacian equations

Enhancing throughput using channel access priorities in frequency hopping network using federated learning

Retraction Note: Enhancing throughput using channel access priorities in frequency hopping network using federated learning

Artikel

The costs of socializing with government officials: A new measure of corporate political connections

A one-year longitudinal study on the mediating role of problematic TikTok use and gender differences in the association between academic stress and academic procrastination

The role of Down syndrome cell adhesion molecule in Down syndrome

Functional insights into the role of a bacterial virulence factor and a host factor in Neisseria gonorrhoeae infection

A global compactness result with applications to a Hardy-Sobolev critical elliptic system involving coupled perturbation terms

Progress and Promise of Nitric Oxide‐Releasing Platforms

A novel approach to fuzzy soft sets in decision making based on grey relational analysis and MYCIN certainty factor

Cultural heritage institutions wishing to register will find more information here.

Fields marked * need to be filled in.

Username*

Please enter your username

Email*

Please enter your email address

Please do not fill this field

First name

Last name

Password*

Please enter your password

Confirm password*

Please enter the same password

I have read the terms of use and the privacy policy for the collection of personal data and accept them. *

This field is required.

I would like to subscribe to the newsletter of the Deutsche Digitale Bibliothek. See newsletter subscription info.

Account created

Your "My DDB" account has been successfully created. Before you can log in to your account, you must click the confirmation link in the message we just sent to the email address you provided.

Interferon‐mediated repression of miR ‐324‐5p potentiates necroptosis to facilitate antiviral defense

Object Details

References and Relationships

Contributors, Places and Time

Further information

Data provider

Associated

Other Objects (12)

Structural model of intelligence beliefs, motivational beliefs, academic self-handicapping and academic adjustment in Chinese undergraduate students

Numb family proteins: novel players in cardiac morphogenesis and cardiac progenitor cell differentiation

Normalized solutions to a class of (2, q)-Laplacian equations

Enhancing throughput using channel access priorities in frequency hopping network using federated learning

Retraction Note: Enhancing throughput using channel access priorities in frequency hopping network using federated learning

The costs of socializing with government officials: A new measure of corporate political connections

A one-year longitudinal study on the mediating role of problematic TikTok use and gender differences in the association between academic stress and academic procrastination

The role of Down syndrome cell adhesion molecule in Down syndrome

Functional insights into the role of a bacterial virulence factor and a host factor in Neisseria gonorrhoeae infection

A global compactness result with applications to a Hardy-Sobolev critical elliptic system involving coupled perturbation terms

Progress and Promise of Nitric Oxide‐Releasing Platforms

A novel approach to fuzzy soft sets in decision making based on grey relational analysis and MYCIN certainty factor

Structural model of intelligence beliefs, motivational beliefs, academic self-handicapping and academic adjustment in Chinese undergraduate students

Numb family proteins: novel players in cardiac morphogenesis and cardiac progenitor cell differentiation

Normalized solutions to a class of (2, q)-Laplacian equations

Enhancing throughput using channel access priorities in frequency hopping network using federated learning

Retraction Note: Enhancing throughput using channel access priorities in frequency hopping network using federated learning

The costs of socializing with government officials: A new measure of corporate political connections

A one-year longitudinal study on the mediating role of problematic TikTok use and gender differences in the association between academic stress and academic procrastination

The role of Down syndrome cell adhesion molecule in Down syndrome

Functional insights into the role of a bacterial virulence factor and a host factor in Neisseria gonorrhoeae infection

A global compactness result with applications to a Hardy-Sobolev critical elliptic system involving coupled perturbation terms

Progress and Promise of Nitric Oxide‐Releasing Platforms

A novel approach to fuzzy soft sets in decision making based on grey relational analysis and MYCIN certainty factor

Structural model of intelligence beliefs, motivational beliefs, academic self-handicapping and academic adjustment in Chinese undergraduate students

Numb family proteins: novel players in cardiac morphogenesis and cardiac progenitor cell differentiation

Normalized solutions to a class of (2, q)-Laplacian equations

Enhancing throughput using channel access priorities in frequency hopping network using federated learning

Retraction Note: Enhancing throughput using channel access priorities in frequency hopping network using federated learning

The costs of socializing with government officials: A new measure of corporate political connections

A one-year longitudinal study on the mediating role of problematic TikTok use and gender differences in the association between academic stress and academic procrastination

The role of Down syndrome cell adhesion molecule in Down syndrome

Functional insights into the role of a bacterial virulence factor and a host factor in Neisseria gonorrhoeae infection

A global compactness result with applications to a Hardy-Sobolev critical elliptic system involving coupled perturbation terms

Progress and Promise of Nitric Oxide‐Releasing Platforms

A novel approach to fuzzy soft sets in decision making based on grey relational analysis and MYCIN certainty factor

Related objects

Reset password