Preparative Protein Crystallization

Abstract: Preparative protein crystallization can possibly replace one or more chromatographic steps in downstream processing. The development of such crystallization processes is demanding: first, promising principal crystallization conditions must be identified; second, details about the process must be defined; and third, the crystals have to be separated from the mother liquor without putting harm of their crystalline integrity. State‐of‐the‐art about these three steps is developing fast by (i) employing new screening methods which are based on fundamental understanding of the interaction of the protein molecules, (ii) application of existing concepts of technical bulk crystallization of small molecules to preparative protein crystallization, and (iii) making available specific gentle separation machinery.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Preparative Protein Crystallization ; volume:42 ; number:11 ; year:2019 ; pages:2275-2281 ; extent:7 ; Chemical engineering & technology ; 42, Heft 11 (2019), 2275-2281 (gesamt 7)

Beteiligte, Orts- und Zeitangaben

• Urheber: Hubbuch, Jürgen ; Kind, Matthias ; Nirschl, Hermann

Weitere Informationen

• DOI: 10.1002/ceat.201800627
• URN: urn:nbn:de:101:1-2022072009580215755012
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:33 MESZ