Neuromodulation in psychiatric disorders: experimental and clinical evidence for reward and motivation network deep brain stimulation: focus on the medial forebrain bundle
Abstract: Deep brain stimulation (DBS) in psychiatric illnesses has been clinically tested over the past 20 years. The clinical application of DBS to the superolateral branch of the medial forebrain bundle in treatment‐resistant depressed patients—one of several targets under investigation—has shown to be promising in a number of uncontrolled open label trials. However, there are remain numerous questions that need to be investigated to understand and optimize the clinical use of DBS in depression, including, for example, the relationship between the symptoms, the biological substrates/projections and the stimulation itself. In the context of precision and customized medicine, the current paper focuses on clinical and experimental research of medial forebrain bundle DBS in depression or in animal models of depression, demonstrating how clinical and scientific progress can work in tandem to test the therapeutic value and investigate the mechanisms of this experimental treatment. As one of the hypotheses is that depression engenders changes in the reward and motivational networks, the review looks at how stimulation of the medial forebrain bundle impacts the dopaminergic system
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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European journal of neuroscience : EJN. - 53, 1 (2021) , 89-113, ISSN: 1460-9568
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2020
- Creator
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Döbrössy, Máté D.
Ramanathan, Chockalingam
Ashouri, Danesh
Tong, Yixin
Schläpfer, Thomas
Coenen, Volker Arnd
- DOI
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10.1111/ejn.14975
- URN
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urn:nbn:de:bsz:25-freidok-1698292
- Rights
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Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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25.03.2025, 1:51 PM CET
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Associated
- Döbrössy, Máté D.
- Ramanathan, Chockalingam
- Ashouri, Danesh
- Tong, Yixin
- Schläpfer, Thomas
- Coenen, Volker Arnd
- Universität
Time of origin
- 2020
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Biological mechanisms of neurostimulation: An in situ hybridization based study comparing Deep Brain Stimulation and Optogenetic stimulation of the Medial Forebrain Bundle
Deep brain stimulation in animal models of depression: a platform for investigating underlying mechanisms of the diesease : acute and chronic effects of medial forebrain bundle deep brain stimulation on the mesolimbic/-cortical network dynamics in the rodent
Optogenetic neuromodulation in a rodent model of depression
The anatomy of the human medial forebrain bundle : : ventral tegmental area connections to reward-associated subcortical and frontal lobe regions
Telemetry based measurements of the physiological effects of stress and the role of noradrenaline in the stress response following Deep Brain Stimulation of the medial forebrain bundle
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Feasibility and safety of continuous and chronic bilateral deep brain stimulation of the medial forebrain bundle in the naïve Sprague-Dawley rat
Neuromodulation in pPsychiatric disorders : : experimental and clinical evidence for reward and motivation network deep brain stimulation
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New insights into in vivo dopamine physiology and neurostimulation: A fiber photometry study highlighting the impact of medial forebrain bundle deep brain stimulation on the nucleus accumbens
Projektion individueller Faserbahnen in den neurochirurgischen Operationssitus
Morphologie und Morphometrie des Temporallappens und des Unterhorns des Seitenventrikels bei Schizophrenie : In-vivo-Kernspinstudie
Biological mechanisms of neurostimulation: An in situ hybridization based study comparing Deep Brain Stimulation and Optogenetic stimulation of the Medial Forebrain Bundle
Deep brain stimulation in animal models of depression: a platform for investigating underlying mechanisms of the diesease : acute and chronic effects of medial forebrain bundle deep brain stimulation on the mesolimbic/-cortical network dynamics in the rodent
Optogenetic neuromodulation in a rodent model of depression
The anatomy of the human medial forebrain bundle : : ventral tegmental area connections to reward-associated subcortical and frontal lobe regions
Telemetry based measurements of the physiological effects of stress and the role of noradrenaline in the stress response following Deep Brain Stimulation of the medial forebrain bundle
Superolateral medial forebrain bundle deep brain stimulation for obsessive-compulsive disorder in both spouses of a married couple - couple case report
Feasibility and safety of continuous and chronic bilateral deep brain stimulation of the medial forebrain bundle in the naïve Sprague-Dawley rat
Neuromodulation in pPsychiatric disorders : : experimental and clinical evidence for reward and motivation network deep brain stimulation
Machine learning - aided personalized DTI tractographic planning for deep brain stimulation of the superolateral medial forebrain bundle using HAMLET
New insights into in vivo dopamine physiology and neurostimulation: A fiber photometry study highlighting the impact of medial forebrain bundle deep brain stimulation on the nucleus accumbens
Projektion individueller Faserbahnen in den neurochirurgischen Operationssitus
Morphologie und Morphometrie des Temporallappens und des Unterhorns des Seitenventrikels bei Schizophrenie : In-vivo-Kernspinstudie
Biological mechanisms of neurostimulation: An in situ hybridization based study comparing Deep Brain Stimulation and Optogenetic stimulation of the Medial Forebrain Bundle
Deep brain stimulation in animal models of depression: a platform for investigating underlying mechanisms of the diesease : acute and chronic effects of medial forebrain bundle deep brain stimulation on the mesolimbic/-cortical network dynamics in the rodent
Optogenetic neuromodulation in a rodent model of depression
The anatomy of the human medial forebrain bundle : : ventral tegmental area connections to reward-associated subcortical and frontal lobe regions
Telemetry based measurements of the physiological effects of stress and the role of noradrenaline in the stress response following Deep Brain Stimulation of the medial forebrain bundle
Superolateral medial forebrain bundle deep brain stimulation for obsessive-compulsive disorder in both spouses of a married couple - couple case report
Feasibility and safety of continuous and chronic bilateral deep brain stimulation of the medial forebrain bundle in the naïve Sprague-Dawley rat
Neuromodulation in pPsychiatric disorders : : experimental and clinical evidence for reward and motivation network deep brain stimulation
Machine learning - aided personalized DTI tractographic planning for deep brain stimulation of the superolateral medial forebrain bundle using HAMLET