Drug Allergy in Children: Adverse Reactions after Skin Testing

Introduction: Skin tests are one of the most widely used diagnostic tools for suspected drug allergies in children. Studies on systemic reactions occurring during skin testing with allergens have mostly been conducted in pediatric and adult patient groups together. However, data on adverse reactions including allergic reactions after drug skin tests in children are scarce. It is aimed to determine the adverse reactions after skin test in children with suspected drug allergy. Methods: Patients who underwent a drug skin test due to the suspicion of drug allergy between May 2017 and June 2020 were evaluated, retrospectively. Data about adverse reactions seen after skin testing at the testing area in the clinic were analyzed. Results: The study included 1,073 children (585 [54.5%] boys and 488 [45.5%] girls) with a median age of 7.5 years. A total of 12 (1.1%) reactions were detected after skin testing, and 4 (0.4%) of them were allergic reactions. Of the allergic reactions, three were anaphylaxis and one was urticaria. Two of the reactions (1 anaphylaxis and 1 urticaria) were detected after the skin prick test and the remaining 2 were detected after intradermal test. Three of the nonallergic reactions were considered as vasovagal reactions and seven were considered as nonspecific and anxiety-related reactions. Conclusion: Although drug skin tests were generally well-tolerated and adverse reactions were rare, severe allergic reactions including anaphylaxis may ensue. Skin tests should be necessarily performed in clinical settings in experienced centers.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Drug Allergy in Children: Adverse Reactions after Skin Testing ; volume:185 ; number:1 ; year:2024 ; pages:56-62 ; extent:7
International archives of allergy and immunology ; 185, Heft 1 (2024), 56-62 (gesamt 7)

Urheber
Karavaizoglu, Cagla
Suleyman, Ayse
Yavuz Alıc, Roza
Dolu, Kazım Okan
Yucel, Esra
Demirkale, Zeynep Hızlı
Cimen, Sevgi Sipahi
Ozdemir, Cevdet
Tamay, Zeynep Ulker

DOI
10.1159/000533641
URN
urn:nbn:de:101:1-2024012423221313948465
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:35 MESZ

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Beteiligte

  • Karavaizoglu, Cagla
  • Suleyman, Ayse
  • Yavuz Alıc, Roza
  • Dolu, Kazım Okan
  • Yucel, Esra
  • Demirkale, Zeynep Hızlı
  • Cimen, Sevgi Sipahi
  • Ozdemir, Cevdet
  • Tamay, Zeynep Ulker

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