Mitochondrial fatty acid beta-oxidation : a possible therapeutic target for skeletal muscle lipotoxicity in peripheral artery disease myopathy

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Abstract: Peripheral artery disease (PAD) is an atherosclerotic disease impacting over 200 million individuals and the prevalence increases with age. PAD occurs when plaque builds up within the peripheral arteries, leading to reduced blood flow and oxygen supply to the outer extremities. Individuals who experience PAD suffer from ischemia, which is typically accompanied by significant damage to skeletal muscles. Additionally, this tissue damage affects mitochondria, causing them to become dysregulated and dysfunctional, resulting in decreased metabolic rates. As there is no known cure for PAD, researchers are exploring potential therapeutic targets by examining coexisting cardiovascular conditions and metabolic risk factors, such as the aging process. Among these comorbidities, type-two diabetes mellitus and obesity are particularly common in PAD cases. These conditions, along with aging itself, are associated with an elevated accumulation of ectopic lipids within skeletal muscles, similar t.... https://www.excli.de/index.php/excli/article/view/7004

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Mitochondrial fatty acid beta-oxidation ; volume:23 ; year:2024
EXCLI journal ; 23 (2024)

Creator: Bradley, Cassandra E.
Fletcher, Emma
Wilkinson, Trevor
Ring, Andrew
Ferrer, Lucas Cardona
Miserlis, Dimitrios
Pacher, Pal
Koutakis, Panagiotis

DOI: 10.17179/excli2024-7004

URN: urn:nbn:de:101:1-2406210315565.524163180244

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:54 AM CEST

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Bradley, Cassandra E.
Fletcher, Emma
Wilkinson, Trevor
Ring, Andrew
Ferrer, Lucas Cardona
Miserlis, Dimitrios
Pacher, Pal
Koutakis, Panagiotis

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Mitochondrial fatty acid beta-oxidation : a possible therapeutic target for skeletal muscle lipotoxicity in peripheral artery disease myopathy

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Other Objects (12)

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Altered skeletal muscle (mitochondrial) properties in patients with mitochondrial DNA single deletion myopathy

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