circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis
Abstract: CircularRNAs (circRNAs) are collectively involved in periodontitis. The aim of this study was to explore the roles of circ_0062491 in osteogenic differentiation of PDLSCs and provide a novel method for periodontitis treatment. mRNA and protein expression levels were measured by qRT-PCR and western blotting. Alkaline phosphatase (ALP) and alizarin red S (ARS) staining were used to detect the activity of osteogenesis. Furthermore, the interactions between miR-142-5p and circ_0062491/IGF1 were verified by a luciferase reporter assay. circ_0062491 was suppressed in PDL tissues of periodontitis patients and overexpressed in osteogenesis-induced PDLSCs. Upregulated circ_0062491 promoted osteogenic differentiation of PDLSCs. miR-142-5p was verified to be a target of circ_0062491, and the overexpression of miR-142-5p suppressed the osteogenic differentiation of PDLSCs induced by circ_0062491 Additionally, miR-142-5p targeted IGF1, and silenced IGF1 abrogated the effects of suppressed miR-142-5p on osteogenic differentiation of PDLSCs. In conclusion, circ_0062491 acted as a competing endogenous RNA to regulate osteogenic differentiation of PDLSCs via the miR-142-5p/IGF1 axis.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis ; volume:17 ; number:1 ; year:2022 ; pages:638-647 ; extent:10
Open medicine ; 17, Heft 1 (2022), 638-647 (gesamt 10)
- Creator
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Wang, Chunlin
Gong, Junxia
Li, Dai
Xing, Xianghui
- DOI
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10.1515/med-2022-0442
- URN
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urn:nbn:de:101:1-2022071515420410766300
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:21 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Wang, Chunlin
- Gong, Junxia
- Li, Dai
- Xing, Xianghui
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Retraction of “circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis”
M6A demethylase FTO-stabilized exosomal circBRCA1 alleviates oxidative stress-induced granulosa cell damage via the miR-642a-5p/FOXO1 axis
Knockdown of circ-FANCA alleviates LPS-induced HK2 cell injury via targeting miR-93-5p/OXSR1 axis in septic acute kidney injury
circ_0029463 promotes osteoclast differentiation by mediating miR-134-5p/Rab27a axis
CircZNF609 and circNFIX as possible regulators of glioblastoma pathogenesis via miR-145-5p/EGFR axis
Dexmedetomidine pretreatment alleviates ropivacaine-induced neurotoxicity via the miR-10b-5p/BDNF axis
CircAKT3 alleviates postoperative cognitive dysfunction by stabilizing the feedback cycle of miR-106a-5p/HDAC4/MEF2C axis in hippocampi of aged mice
A nanodrug system overexpressed circRNA_0001805 alleviates nonalcoholic fatty liver disease via miR-106a-5p/miR-320a and ABCA1/CPT1 axis
circ_0006789 promotes cervical cancer development via the miR-615-5p/HSF1 axis
Circ-TRIO promotes TNBC progression by regulating the miR-432-5p/CCDC58 axis
The novel circ_0028171/miR-218-5p/IKBKB axis promotes osteosarcoma cancer progression
CircCRIM1 promotes nasopharyngeal carcinoma progression via the miR-34c-5p/FOSL1 axis
Retraction of “circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis”
M6A demethylase FTO-stabilized exosomal circBRCA1 alleviates oxidative stress-induced granulosa cell damage via the miR-642a-5p/FOXO1 axis
Knockdown of circ-FANCA alleviates LPS-induced HK2 cell injury via targeting miR-93-5p/OXSR1 axis in septic acute kidney injury
circ_0029463 promotes osteoclast differentiation by mediating miR-134-5p/Rab27a axis
CircZNF609 and circNFIX as possible regulators of glioblastoma pathogenesis via miR-145-5p/EGFR axis
Dexmedetomidine pretreatment alleviates ropivacaine-induced neurotoxicity via the miR-10b-5p/BDNF axis
CircAKT3 alleviates postoperative cognitive dysfunction by stabilizing the feedback cycle of miR-106a-5p/HDAC4/MEF2C axis in hippocampi of aged mice
A nanodrug system overexpressed circRNA_0001805 alleviates nonalcoholic fatty liver disease via miR-106a-5p/miR-320a and ABCA1/CPT1 axis
circ_0006789 promotes cervical cancer development via the miR-615-5p/HSF1 axis
Circ-TRIO promotes TNBC progression by regulating the miR-432-5p/CCDC58 axis
The novel circ_0028171/miR-218-5p/IKBKB axis promotes osteosarcoma cancer progression