An Organocatalytic and Stereoselective Vinylogous Domino Process towards Thiochromans
Abstract: A highly diastereoselective organocatalyzed domino vinylogous sulfa‐Michael‐aldol‐cyclocondensation (VMAC) reaction has been developed using alkylidene Meldrum's acid as dienes highlighting two vinylogous steps, an unprecedented sulfa‐1,6‐conjugate addition and a diastereoselective aldol reaction triggering a formal (4+2) cycloaddition. This work opens a new route towards bio‐relevant and original tricyclic thiochroman derivatives.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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An Organocatalytic and Stereoselective Vinylogous Domino Process towards Thiochromans ; day:19 ; month:06 ; year:2023 ; extent:6
Chemistry - a European journal ; (19.06.2023) (gesamt 6)
- Urheber
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Milbeo, Pierre
Lebrêne, Arthur
Savchuk, Mariia
Vo‐Thanh, Giang
Oudeyer, Sylvain
Beucher, Hélène
Brière, Jean‐François
- DOI
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10.1002/chem.202301311
- URN
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urn:nbn:de:101:1-2023061915153878533829
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 14.08.2025, 10:56 MESZ
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Beteiligte
- Milbeo, Pierre
- Lebrêne, Arthur
- Savchuk, Mariia
- Vo‐Thanh, Giang
- Oudeyer, Sylvain
- Beucher, Hélène
- Brière, Jean‐François
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