Portulaca oleracea L. Extract Ameliorates Intestinal Inflammation by Regulating Endoplasmic Reticulum Stress and Autophagy
Scope: To investigate the role of endoplasmic reticulum stress (ERS)‐induced autophagy in inflammatory bowel disease (IBD) and the intervention mechanism of Portulaca oleracea L. (POL) extract, a medicinal herb with anti‐inflammatory, antioxidant, immune‐regulating, and antitumor properties, in vitro and in vivo. Methods and Results: An IL‐10‐deficient mouse model is used for in vivo experiments; a thapsigargin (Tg)‐stimulated ERS model of human colonic mucosal epithelial cells (HIECs) is used for in vitro experiments. The levels of ERS‐autophagy‐related proteins are examined by immunofluorescence and Western blot. Cellular ultrastructure is assessed with transmission electron microscopy. POL extract promotes a healing effect on colitis by regulating ERS‐autophagy through the protein kinase R‐like endoplasmic reticulum kinase (PERK)‐eukaryotic initiation factor 2α (eIF2α)/Beclin1‐microtubule‐associated protein light chain 3II (LC3II) pathway. Conclusion: Overall, the results of this study further confirm the anti‐inflammatory mechanism and protective effect of POL extract and provide a new research avenue for the clinical treatment of IBD.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Portulaca oleracea L. Extract Ameliorates Intestinal Inflammation by Regulating Endoplasmic Reticulum Stress and Autophagy ; day:09 ; month:01 ; year:2022 ; extent:13
Molecular nutrition & food research ; (09.01.2022) (gesamt 13)
- Urheber
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Zhang, Ziwei
Qiao, Dan
Zhang, Yali
Chen, Qian
Chen, Yujun
Tang, Yingjue
Que, Renye
Chen, Ying
Zheng, Lie
Dai, Yancheng
Tang, Zhipeng
- DOI
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10.1002/mnfr.202100791
- URN
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urn:nbn:de:101:1-2022011014011598097645
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:28 MESZ
Datenpartner
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Beteiligte
- Zhang, Ziwei
- Qiao, Dan
- Zhang, Yali
- Chen, Qian
- Chen, Yujun
- Tang, Yingjue
- Que, Renye
- Chen, Ying
- Zheng, Lie
- Dai, Yancheng
- Tang, Zhipeng
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