Immunosuppressant flavonoids from Scutellaria baicalensis
Abstract: Some plants used in Traditional Chinese Medicine serve as treatment for disease states where a suppression of the cellular immune response is desired. However, the compounds responsible for the immunosuppressant effects of these plants are not necessarily known.
The immunosuppressant compounds in the roots of Scutellaria baicalensis, one of the most promising plants identified in a previous screening, were tracked by HPLC activity profiling and concomitant on-line spectroscopic analysis. Compounds were then isolated by preparative chromatography, and structures elucidated by spectroscopic methods. Twelve flavonoids (5–16) were identified from the active time windows, and structurally related flavones 2, 4, and 17, and flavanones 1 and 3 were isolated from adjacent fractions. All flavonoids possessed an unusual substitution pattern on the B-ring, with an absence of substituents at C-3 and C-4. Compounds 11, 13, 14, and 16 inhibited T-cell proliferation (IC50 values at 12.1–39 μM) at non-cytotoxic concentrations. The findings may support the use of S. baicalensis in disorders where a modulation of the cellular immune response is desirable
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Notes
-
Biomedicine & pharmacotherapy. - 144 (2021) , 112326, ISSN: 1950-6007
- Event
-
Veröffentlichung
- (where)
-
Freiburg
- (who)
-
Universität
- (when)
-
2021
- Creator
-
Syafni, Nova
Devi, Seema
Zimmermann-Klemd, Amy Marisa
Reinhardt, Jakob K.
Danton, Ombeline
Gründemann, Carsten
Hamburger, Matthias
- DOI
-
10.1016/j.biopha.2021.112326
- URN
-
urn:nbn:de:bsz:25-freidok-2220309
- Rights
-
Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:21 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Syafni, Nova
- Devi, Seema
- Zimmermann-Klemd, Amy Marisa
- Reinhardt, Jakob K.
- Danton, Ombeline
- Gründemann, Carsten
- Hamburger, Matthias
- Universität
Time of origin
- 2021
Other Objects (12)
Biotransformations from and to methylated flavonoids
The bacterial lectin LecA from P. aeruginosa alters membrane organization by dispersing ordered domains
Multistage fluorite mineralization in the southern Black Forest, Germany: evidence from rare earth element (REE) geochemistry
The challenge of comparing pollen-based quantitative vegetation reconstructions with outputs from vegetation models – a European perspective
The unified redox scale for all solvents: consistency and gibbs transfer energies of electrolytes from their constituent single ions
Neutralizing the impact of the virulence factor LecA from Pseudomonas aeruginosa on human cells with new glycomimetic inhibitors
Colluvial sediments originating from past land-use activities in the Erzgebirge Mountains, Central Europe: occurrence, properties, and historic environmental implications
Isoprenylated flavonoids and clerodane diterpenoids from Dodonaea viscosa
Flavonoids of the Caryophyllaceae
Three new Bronzes from Gilgit
Mechanism of mineral reactions inferred from textures of impure dolomitic marbles from East Greenland
Frequency correlations in reflection from random media
Biotransformations from and to methylated flavonoids
The bacterial lectin LecA from P. aeruginosa alters membrane organization by dispersing ordered domains
Multistage fluorite mineralization in the southern Black Forest, Germany: evidence from rare earth element (REE) geochemistry
The challenge of comparing pollen-based quantitative vegetation reconstructions with outputs from vegetation models – a European perspective
The unified redox scale for all solvents: consistency and gibbs transfer energies of electrolytes from their constituent single ions
Neutralizing the impact of the virulence factor LecA from Pseudomonas aeruginosa on human cells with new glycomimetic inhibitors
Colluvial sediments originating from past land-use activities in the Erzgebirge Mountains, Central Europe: occurrence, properties, and historic environmental implications
Isoprenylated flavonoids and clerodane diterpenoids from Dodonaea viscosa
Flavonoids of the Caryophyllaceae
Three new Bronzes from Gilgit
Mechanism of mineral reactions inferred from textures of impure dolomitic marbles from East Greenland
Frequency correlations in reflection from random media
Biotransformations from and to methylated flavonoids
The bacterial lectin LecA from P. aeruginosa alters membrane organization by dispersing ordered domains
Multistage fluorite mineralization in the southern Black Forest, Germany: evidence from rare earth element (REE) geochemistry
The challenge of comparing pollen-based quantitative vegetation reconstructions with outputs from vegetation models – a European perspective
The unified redox scale for all solvents: consistency and gibbs transfer energies of electrolytes from their constituent single ions
Neutralizing the impact of the virulence factor LecA from Pseudomonas aeruginosa on human cells with new glycomimetic inhibitors
Colluvial sediments originating from past land-use activities in the Erzgebirge Mountains, Central Europe: occurrence, properties, and historic environmental implications
Isoprenylated flavonoids and clerodane diterpenoids from Dodonaea viscosa
Flavonoids of the Caryophyllaceae
Three new Bronzes from Gilgit
Mechanism of mineral reactions inferred from textures of impure dolomitic marbles from East Greenland