Holistic Equivalent Circuit Model for Capacitive Extracellular Stimulation
Abstract: Capacitive extracellular stimulation is a common method in implanted stimulation electrodes. The basis for investigating the transmission of stimuli from an electrode to adhered cells are in vitro experiments using calcium imaging or patch clamp measurements. Computational spatial models are used to simulate the mechanism of signal transmission at the cell-electrode interface but require high computing power. In this work, the Stern model to characterize the electrochemical double-layer (EDL) formation and a modified two-domain model are combined into a holistic equivalent circuit modelling capacitive cell stimulation. The described parameters can be directly associated with physicochemical effects. A simulation of the involved control and measurement systems allows the validation of the model with in vitro patch clamp recordings. The relationship of the cell’s distance to the electrode and efficacy of signal transmission could be observed. With this concept we aim to convert different complex approaches into a simple model and thus give an overview of the mechanisms of stimulation. We want to facilitate the interpretation of measured signals especially in voltage clamp measurements.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Holistic Equivalent Circuit Model for Capacitive Extracellular Stimulation ; volume:8 ; number:2 ; year:2022 ; pages:777-780 ; extent:4
Current directions in biomedical engineering ; 8, Heft 2 (2022), 777-780 (gesamt 4)
- Creator
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Polz, Mathias
Rath, Thomas
Trimmel, Gregor
Stoppacher, Sara
Nowakowska, Marta
Kornmüller, Karin
Shestha, Niroj
Baumgartner, Christian
Rienmüller, Theresa
- DOI
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10.1515/cdbme-2022-1198
- URN
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urn:nbn:de:101:1-2022090315362937226223
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:26 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Polz, Mathias
- Rath, Thomas
- Trimmel, Gregor
- Stoppacher, Sara
- Nowakowska, Marta
- Kornmüller, Karin
- Shestha, Niroj
- Baumgartner, Christian
- Rienmüller, Theresa
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