Protein transport along the presequence pathway

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Abstract: Most mitochondrial proteins are nuclear-encoded and imported by the protein import machinery based on specific targeting signals. The proteins that carry an amino-terminal targeting signal (presequence) are imported via the presequence import pathway that involves the translocases of the outer and inner membranes – TOM and TIM23 complexes. In this article, we discuss how mitochondrial matrix and inner membrane precursor proteins are imported along the presequence pathway in Saccharomyces cerevisiae with a focus on the dynamics of the TIM23 complex, and further update with some of the key findings that advanced the field in the last few years.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Protein transport along the presequence pathway ; volume:404 ; number:8-9 ; year:2023 ; pages:807-812 ; extent:06
Biological chemistry ; 404, Heft 8-9 (2023), 807-812 (gesamt 06)

Creator: Makki, Abhijith
Rehling, Peter

DOI: 10.1515/hsz-2023-0133

URN: urn:nbn:de:101:1-2023090714224832013364

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 8:45 AM UTC

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Makki, Abhijith
Rehling, Peter

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Protein transport along the presequence pathway

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Other Objects (12)

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