RNA Dynamics by NMR Spectroscopy

Abstract: An ever‐increasing number of functional RNAs require a mechanistic understanding. RNA function relies on changes in its structure, so‐called dynamics. To reveal dynamic processes and higher energy structures, new NMR methods have been developed to elucidate these dynamics in RNA with atomic resolution. In this Review, we provide an introduction to dynamics novices and an overview of methods that access most dynamic timescales, from picoseconds to hours. Examples are provided as well as insight into theory, data acquisition and analysis for these different methods. Using this broad spectrum of methodology, unprecedented detail and invisible structures have been obtained and are reviewed here. RNA, though often more complicated and therefore neglected, also provides a great system to study structural changes, as these RNA structural changes are more easily defined—Lego like—than in proteins, hence the numerous revelations of RNA excited states.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: RNA Dynamics by NMR Spectroscopy ; volume:20 ; number:21 ; year:2019 ; pages:2685-2710 ; extent:26 ; ChemBioChem ; 20, Heft 21 (2019), 2685-2710 (gesamt 26)

Contributors, Places and Time

• Creator: Marušič, Maja ; Schlagnitweit, Judith ; Petzold, Katja

Further information

• DOI: 10.1002/cbic.201900072
• URN: urn:nbn:de:101:1-2022081409371910975451
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:31 AM CEST