RNA Dynamics by NMR Spectroscopy

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Abstract: An ever‐increasing number of functional RNAs require a mechanistic understanding. RNA function relies on changes in its structure, so‐called dynamics. To reveal dynamic processes and higher energy structures, new NMR methods have been developed to elucidate these dynamics in RNA with atomic resolution. In this Review, we provide an introduction to dynamics novices and an overview of methods that access most dynamic timescales, from picoseconds to hours. Examples are provided as well as insight into theory, data acquisition and analysis for these different methods. Using this broad spectrum of methodology, unprecedented detail and invisible structures have been obtained and are reviewed here. RNA, though often more complicated and therefore neglected, also provides a great system to study structural changes, as these RNA structural changes are more easily defined—Lego like—than in proteins, hence the numerous revelations of RNA excited states.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
RNA Dynamics by NMR Spectroscopy ; volume:20 ; number:21 ; year:2019 ; pages:2685-2710 ; extent:26
ChemBioChem ; 20, Heft 21 (2019), 2685-2710 (gesamt 26)

Urheber
Marušič, Maja
Schlagnitweit, Judith
Petzold, Katja

DOI
10.1002/cbic.201900072
URN
urn:nbn:de:101:1-2022081409371910975451
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:31 MESZ

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