Visible‐Light Photoredox Catalytic Direct N ‐(Het) Arylation of Lactams

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Abstract: Lactam rings are essential structural motifs in organic chemistry, widely present in natural products and clinically important drugs, such as antibiotics and antiepileptics. Existing methods for synthesizing N‐functionalized lactams often require harsh conditions, toxic reagents, or complex catalytic systems. Here, we report a mild and efficient photochemical approach for generating N‐centered radicals, enabling straightforward N‐heteroarylation of lactams. This versatile method enables the synthesis of a range of N‐(het) arylated lactams and is effective even in aqueous media, facilitating the functionalization of biomolecules. Furthermore, the photochemical reaction is easily scalable under continuous flow conditions, making it highly suitable for large‐scale applications.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Visible‐Light Photoredox Catalytic Direct N ‐(Het) Arylation of Lactams ; day:14 ; month:02 ; year:2025 ; extent:9
Chemistry - a European journal ; (14.02.2025) (gesamt 9)

Urheber
Boselli, Monica Fiorenza
Ghosh, Indrajit
Intini, Niccolò
Fattalini, Marco
Puglisi, Alessandra
König, Burkhard
Benaglia, Maurizio

DOI
10.1002/chem.202404385
URN
urn:nbn:de:101:1-2502141317518.627464102469
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:27 MESZ

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