Visible‐Light Photoredox Catalytic Direct N ‐(Het) Arylation of Lactams
Abstract: Lactam rings are essential structural motifs in organic chemistry, widely present in natural products and clinically important drugs, such as antibiotics and antiepileptics. Existing methods for synthesizing N‐functionalized lactams often require harsh conditions, toxic reagents, or complex catalytic systems. Here, we report a mild and efficient photochemical approach for generating N‐centered radicals, enabling straightforward N‐heteroarylation of lactams. This versatile method enables the synthesis of a range of N‐(het) arylated lactams and is effective even in aqueous media, facilitating the functionalization of biomolecules. Furthermore, the photochemical reaction is easily scalable under continuous flow conditions, making it highly suitable for large‐scale applications.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Visible‐Light Photoredox Catalytic Direct N ‐(Het) Arylation of Lactams ; day:14 ; month:02 ; year:2025 ; extent:9
Chemistry - a European journal ; (14.02.2025) (gesamt 9)
- Creator
-
Boselli, Monica Fiorenza
Ghosh, Indrajit
Intini, Niccolò
Fattalini, Marco
Puglisi, Alessandra
König, Burkhard
Benaglia, Maurizio
- DOI
-
10.1002/chem.202404385
- URN
-
urn:nbn:de:101:1-2502141317518.627464102469
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:27 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Boselli, Monica Fiorenza
- Ghosh, Indrajit
- Intini, Niccolò
- Fattalini, Marco
- Puglisi, Alessandra
- König, Burkhard
- Benaglia, Maurizio
Other Objects (12)
Functionalization of sp²-carbon atoms via visible-light photoredox catalysis
Applications of organocatalysed visible-light photoredox reactions for medicinal chemistry
Visible-light photoredox catalysis enabled bromination of phenols and alkenes
The photoredox catalyzed Meerwein arylation
Reductive Cyclization of Unactivated Alkyl Chlorides with Tethered Alkenes under Visible‐Light Photoredox Catalysis
Reductive Cyclization of Unactivated Alkyl Chlorides with Tethered Alkenes under Visible‐Light Photoredox Catalysis
Visible‐Light‐Mediated Photoredox‐Catalyzed N ‐Arylation of NH ‐Sulfoximines with Electron‐Rich Arenes
Covalent Triazine Framework Nanoparticles via Size‐Controllable Confinement Synthesis for Enhanced Visible‐Light Photoredox Catalysis
3D Visible‐Light Invisibility Cloak
Copper-catalyzed asymmetric sp3 C–H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst
Visible‐Light Switching of Metallosupramolecular Assemblies **
Visible-light photoredox-catalyzed C–O bond cleavage of diaryl ethers by acridinium photocatalysts at room temperature
Functionalization of sp²-carbon atoms via visible-light photoredox catalysis
Applications of organocatalysed visible-light photoredox reactions for medicinal chemistry
Visible-light photoredox catalysis enabled bromination of phenols and alkenes
The photoredox catalyzed Meerwein arylation
Reductive Cyclization of Unactivated Alkyl Chlorides with Tethered Alkenes under Visible‐Light Photoredox Catalysis
Reductive Cyclization of Unactivated Alkyl Chlorides with Tethered Alkenes under Visible‐Light Photoredox Catalysis
Visible‐Light‐Mediated Photoredox‐Catalyzed N ‐Arylation of NH ‐Sulfoximines with Electron‐Rich Arenes
Covalent Triazine Framework Nanoparticles via Size‐Controllable Confinement Synthesis for Enhanced Visible‐Light Photoredox Catalysis
3D Visible‐Light Invisibility Cloak
Copper-catalyzed asymmetric sp3 C–H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst
Visible‐Light Switching of Metallosupramolecular Assemblies **
Visible-light photoredox-catalyzed C–O bond cleavage of diaryl ethers by acridinium photocatalysts at room temperature
Functionalization of sp²-carbon atoms via visible-light photoredox catalysis
Applications of organocatalysed visible-light photoredox reactions for medicinal chemistry
Visible-light photoredox catalysis enabled bromination of phenols and alkenes
The photoredox catalyzed Meerwein arylation
Reductive Cyclization of Unactivated Alkyl Chlorides with Tethered Alkenes under Visible‐Light Photoredox Catalysis
Reductive Cyclization of Unactivated Alkyl Chlorides with Tethered Alkenes under Visible‐Light Photoredox Catalysis
Visible‐Light‐Mediated Photoredox‐Catalyzed N ‐Arylation of NH ‐Sulfoximines with Electron‐Rich Arenes
Covalent Triazine Framework Nanoparticles via Size‐Controllable Confinement Synthesis for Enhanced Visible‐Light Photoredox Catalysis
3D Visible‐Light Invisibility Cloak
Copper-catalyzed asymmetric sp3 C–H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst
Visible‐Light Switching of Metallosupramolecular Assemblies **