Chemoselective Activation of Diethyl Phosphonates: Modular Synthesis of Biologically Relevant Phosphonylated Scaffolds
Abstract: Phosphonates have garnered considerable attention for years owing to both their singular biological properties and their synthetic potential. State‐of‐the‐art methods for the preparation of mixed phosphonates, phosphonamidates, phosphonothioates, and phosphinates rely on harsh and poorly selective reaction conditions. We report herein a mild method for the modular preparation of phosphonylated derivatives, several of which exhibit interesting biological activities, that is based on chemoselective activation with triflic anhydride. This procedure enables flexible and even iterative substitution with a broad range of O, S, N, and C nucleophiles.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Chemoselective Activation of Diethyl Phosphonates: Modular Synthesis of Biologically Relevant Phosphonylated Scaffolds ; volume:57 ; number:40 ; year:2018 ; pages:13330-13334 ; extent:5
Angewandte Chemie / International edition. International edition ; 57, Heft 40 (2018), 13330-13334 (gesamt 5)
- Creator
- DOI
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10.1002/anie.201806343
- URN
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urn:nbn:de:101:1-2022082405424017703525
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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07.06.20252025, 10:38 PM CEST
Data provider
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Adler, Pauline
- Pons, Amandine
- Li, Jing
- Heider, Jörg
- Brutiu, Bogdan R.
- Maulide, Nuno
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