A Narrative Review on Translational Research in Acute Brain Injury

Abstract: There has been a constant endeavor to reduce the mortality and morbidity associated with acute brain injury. The associated complex mechanisms involving biomechanics, markers, and neuroprotective drugs/measures have been extensively studied in preclinical studies with an ultimate aim to improve the patients' outcomes. Despite such efforts, only few have been successfully translated into clinical practice. In this review, we shall be discussing the major hurdles in the translation of preclinical results into clinical practice. The need is to choose an appropriate animal model, keeping in mind the species, age, and gender of the animal, choosing suitable outcome measures, ensuring quality of animal trials, and carrying out systematic review and meta-analysis of experimental studies before proceeding to human trials. The interdisciplinary collaboration between the preclinical and clinical scientists will help to design better, meaningful trials which might help a long way in successful translation. Although challenging at this stage, the advent of translational precision medicine will help the integration of mechanism-centric translational medicine and patient-centric precision medicine.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: A Narrative Review on Translational Research in Acute Brain Injury ; day:05 ; month:05 ; year:2022 ; Journal of neuroanaesthesiology and critical care ; (05.05.2022)

Beteiligte, Orts- und Zeitangaben

• Beteiligte Personen und Organisationen: Mahajan, Charu ; Kapoor, Indu ; Prabhakar, Hemanshu

Weitere Informationen

• DOI: 10.1055/s-0042-1744399
• URN: urn:nbn:de:101:1-2022062310482233324304
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:37 MESZ