Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injury

Abstract: Background: Diffuse axonal injury occurs with high acceleration and deceleration forces in traumatic brain injury (TBI). This lesion leads to disarrangement of the neuronal network, which can result in some degree of deficiency. The Extended Glasgow Outcome Scale (GOS-E) is the primary outcome instrument for the evaluation of TBI victims. Diffusion tensor imaging (DTI) assesses white matter (WM) microstructure based on the displacement distribution of water molecules. Objective: To investigate WM microstructure within the first year after TBI using DTI, the patient’s clinical outcomes, and associations. Methods: We scanned 20 moderate and severe TBI victims at 2 months and 1 year after the event. Imaging processing was done with the FMRIB software library; we used the tract-based spatial statistics software yielding fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) for statistical analyses. We computed the average difference between the two measures across subjects and performed a one-sample t-test and threshold-free cluster enhancement, using a corrected p-value < 0.05. Clinical outcomes were evaluated with the GOS-E. We tested for associations between outcome measures and significant mean FA clusters. Results: Significant clusters of altered FA were identified anatomically using the JHU WM atlas. We found increasing spotted areas of FA with time in the right brain hemisphere and left cerebellum. Extensive regions of increased MD, RD, and AD were observed. Patients presented an excellent overall recovery. Conclusions: There were no associations between FA and outcome scores, but we cannot exclude the existence of a small to moderate association.

Angaben zum Objekt

• Weitere Titel: Análise longitudinal do encéfalo por tensor de difusão em lesão axonal difusa
• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Longitudinal whole-brain analysis of multi-subject diffusion data in diffuse axonal injury ; volume:80 ; number:03 ; year:2022 ; pages:280-288 ; Arquivos de neuro-psiquiatria ; 80, Heft 03 (2022), 280-288

Beteiligte, Orts- und Zeitangaben

• Beteiligte Personen und Organisationen: Grassi, Daphine Centola ; Zaninotto, Ana Luiza ; Feltrin, Fabrício Stewan ; Macruz, Fabíola Bezerra de Carvalho ; Otaduy, Maria Concepción García ; Leite, Claudia da Costa ; Guirado, Vinicius Monteiro de Paula ; Paiva, Wellingson Silva ; Andrade, Celi Santos

Weitere Informationen

• DOI: 10.1590/0004-282X-ANP-2020-0595
• URN: urn:nbn:de:101:1-2023031611025336412662
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:49 MESZ