Late-Onset Lennox-Gastaut Syndrome with Chromosome 15q Duplication in Sisters

Abstract: Our study reports two nontwin sisters with late-onset Lennox-Gastaut syndrome and chromosome 15q duplication, showing the evolution, symptoms, diagnosis, and treatment of these patients, with the aim of increasing knowledge about this extremely rare association. They had a variety of generalized seizures types, intellectual disability, electroencephalogram with generalized epileptiform discharges less than 3 Hz, dysmorphisms, and genetic studies with the presence of duplicated chromosome 15. Cases reported here may be related to chromosomal changes inherited from their asymptomatic mother.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Late-Onset Lennox-Gastaut Syndrome with Chromosome 15q Duplication in Sisters ; day:08 ; month:03 ; year:2022 ; Journal of neurosciences in rural practice ; (08.03.2022)

Contributors, Places and Time

• Contributor: Honorato, Marcos Manoel ; Santos, Adriane Cristina Vieira dos ; da Silva, Felipe Luan Lima ; Cremaschi, Renata Carvalho ; Coelho, Fernando Morgadinho

Further information

• DOI: 10.1055/s-0042-1743457
• URN: urn:nbn:de:101:1-2022042812260719721775
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:27 AM CEST