Human hypocretin-deficient narcolepsy - aberrant food choice due to impaired taste?

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Authors demonstrate that patients with narcolepsy type 1 (N1) have more tendency of eat salty snacks after satiety than health volunteers. A few mechanisms to explain the weight gain have been discussed in narcolepsy. The hypocretin-1 deficiency can influence the olfactory system. The olfactory system should be modulated through hypocretin-1 via connections from the hypothalamic to other brain regions. Likewise, hypocretin-1 can be synthesized locally in our olfactory mucosa with possible private role modulating the olfactory. In experimental studies, different kinds of smell influence the preference for type of diet. Olfactory and taste sensations help control of appetite and regulate the quantity and quality of foods that will be chosen. N1 patients have lower levels of hypocretin-1 and consequent inferior olfactory threshold, less olfactory discrimination, and these findings improved after nasal hypocretin-1 administration. It is possible that the hyposmia influenced the quality and quantity of food by narcoleptic patients. We suggest that a complementary analysis of olfactory function should be done concomitant with food preferences to compare narcoleptic patients with and without hypocretin-1 deficiency.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Human hypocretin-deficient narcolepsy - aberrant food choice due to impaired taste? ; volume:10 ; number:02 ; year:2017 ; pages:78-79
Sleep science ; 10, Heft 02 (2017), 78-79

Contributor: Truzzi, Giselle de Martin
Cremaschi, Renata Carvalho
Coelho, Fernando Morgadinho

DOI: 10.5935/1984-0063.20170014

URN: urn:nbn:de:101:1-2023120711290716638945

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:30 AM CEST

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Truzzi, Giselle de Martin
Cremaschi, Renata Carvalho
Coelho, Fernando Morgadinho

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Human hypocretin-deficient narcolepsy - aberrant food choice due to impaired taste?

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Other Objects (12)

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