Nanoscopic Insights of Amphiphilic Peptide against the Oligomer Assembly Process to Treat Huntington's Disease
Abstract: Finding an effective therapeutic regimen is an urgent demand for various neurodegenerative disorders including Huntington's disease (HD). For the difficulties in observing the dynamic aggregation and oligomerization process of mutant Huntingtin (mHtt) in vivo, the evaluation of potential drugs at the molecular protein level is usually restricted. By combing lifetime‐based fluorescence microscopies and biophysical tools, it is showcased that a designed amphiphilic peptide, which targets the mHtt at an early stage, can perturb the oligomer assembly process nanoscopically, suppress the amyloid property of mHtt, conformationally transform the oligomers and/or aggregates of mHtt, and ameliorate mHtt‐induced neurological damage and aggregation in cell and HD mouse models. It is also found that this amphiphilic peptide is able to transport to the brain and rescue the memory deficit through intranasal administration, indicating its targeting specificity in vivo. In summary, a biophotonic platform is provided to investigate the oligomerization/aggregation process in detail that offers insight into the design and effect of a targeted therapeutic agent for Huntington's disease.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Nanoscopic Insights of Amphiphilic Peptide against the Oligomer Assembly Process to Treat Huntington's Disease ; volume:7 ; number:2 ; year:2020 ; extent:13
Advanced science ; 7, Heft 2 (2020) (gesamt 13)
- Urheber
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He, Ruei‐Yu
Lai, Xiang‐Me
Sun, Chia‐Sui
Kung, Te‐Shien
Hong, Jhu‐Ying
Jheng, Yu‐Song
Liao, Wei‐Neng
Chen, Jen‐Kun
Liao, Yung‐Feng
Tu, Pang‐Hsien
Huang, Joseph Jen‐Tse
- DOI
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10.1002/advs.201901165
- URN
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urn:nbn:de:101:1-2022062613103183513165
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:25 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- He, Ruei‐Yu
- Lai, Xiang‐Me
- Sun, Chia‐Sui
- Kung, Te‐Shien
- Hong, Jhu‐Ying
- Jheng, Yu‐Song
- Liao, Wei‐Neng
- Chen, Jen‐Kun
- Liao, Yung‐Feng
- Tu, Pang‐Hsien
- Huang, Joseph Jen‐Tse
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