Stem cells for cardiac regeneration and possible roles of the transforming growth factor-β superfamily

Abstract: Heart failure is a leading cause of death worldwide. Studies of stem cell biology are essential for developing efficient treatments. Recently, we established and characterized c-kit-positive cardiac stem cells from the adult rat heart. Using a MethoCult culture system with a methyl-cellulose-based medium, stem-like left-atrium-derived pluripotent cells could be regulated to differentiate into skeletal/cardiac myocytes or adipocytes with almost 100% purity. Microarray and pathway analyses of these cells showed that transforming growth factor-β1 (TGF-β1) and noggin were significantly involved in the differentiation switch. Furthermore, TGF-β1 may act as a regulator for this switch because it simultaneously inhibits adipogenesis and activates myogenesis in a dose-dependent manner. However, the effect of TGF-β varies with developmental stage, dosage, and timing of treatment. In the present review, the findings of recent studies, in particular the use of c-kit-positive cardiac stem cells, are discussed. The effects of the TGF-β superfamily on differentiation, especially on adipogenesis and/or myogenesis, have important implications for future regenerative medicine.

Objekt anzeigen

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Stem cells for cardiac regeneration and possible roles of the transforming growth factor-β superfamily ; volume:3 ; number:1 ; year:2012 ; pages:99-106 ; Biomolecular concepts ; 3, Heft 1 (2012), 99-106

Beteiligte, Orts- und Zeitangaben

• Urheber: Kawaguchi, Nanako

Weitere Informationen

• DOI: 10.1515/bmc.2011.049
• URN: urn:nbn:de:101:1-2409241654375.267908270455
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.