Future Directions for Respiratory Muscle Training in Neuromuscular Disorders: A Scoping Review

Abstract: Background: Respiratory muscle training (RMT) aims to improve inspiratory and/or expiratory muscle function in neuromuscular disorders (NMDs). A comprehensive overview of the available literature is lacking. This scoping review explores methodological characteristics, (adverse) effects, and adherence of RMT studies in NMDs. Moreover, it identifies limitations and research gaps in the literature and provides future research directions. Summary: Eligible studies were identified using MEDLINE, Embase, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials databases. Three reviewers independently selected articles. Inclusion criteria were English language, original research articles on RMT using a device, patients with an NMD, and pulmonary function tests or respiratory muscle strength as outcome measures. We included NMDs with slow, intermediate and fast progression. Exclusion criteria were critically ill patients, weaning from mechanical ventilation, other neurological disorders, and RMT combined with non-respiratory interventions. One reviewer extracted the data on patients’ characteristics, methodological characteristics, results of outcome measures, adverse events, and patient adherence. Forty-five studies were identified. We found a large diversity in study designs and training protocols. The effects of RMT on respiratory muscle strength and/or endurance are variable. Patient adherence was high and no serious adverse events were reported. Key Messages: The diversity in studies across the available literature precludes definitive conclusions regarding the effects of RMT on respiratory muscle function and clinically relevant outcomes in NMDs. Therefore, well-powered and -designed studies that focus on clinically relevant outcomes and assess whether RMT can improve or offset deterioration of respiratory muscle weakness in NMDs are needed.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Future Directions for Respiratory Muscle Training in Neuromuscular Disorders: A Scoping Review ; volume:103 ; number:10 ; year:2024 ; pages:601-621 ; extent:21 ; Respiration ; 103, Heft 10 (2024), 601-621 (gesamt 21)

Contributors, Places and Time

• Creator: van Kleef, Esmee S.B. ; Poddighe, Diego ; Caleffi Pereira, Mayra ; Schuurbiers, Marit L. ; Groothuis, Jan T. ; Wijkstra, Peter J. ; Voermans, Nicol C. ; Gosselink, Rik ; Langer, Daniel ; Doorduin, Jonne

Further information

• DOI: 10.1159/000539726
• URN: urn:nbn:de:101:1-2410100057197.072353159170
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:28 AM CEST