Multi‐Omics Analysis Reveals Translational Landscapes and Regulations in Mouse and Human Oocyte Aging
Abstract: Abnormal resumption of meiosis and decreased oocyte quality are hallmarks of maternal aging. Transcriptional silencing makes translational control an urgent task during meiosis resumption in maternal aging. However, insights into aging‐related translational characteristics and underlying mechanisms are limited. Here, using multi‐omics analysis of oocytes, it is found that translatomics during aging is related to changes in the proteome and reveals decreased translational efficiency with aging phenotypes in mouse oocytes. Translational efficiency decrease is associated with the N6‐methyladenosine (m6A) modification of transcripts. It is further clarified that m6A reader YTHDF3 is significantly decreased in aged oocytes, inhibiting oocyte meiotic maturation. YTHDF3 intervention perturbs the translatome of oocytes and suppress the translational efficiency of aging‐associated maternal factors, such as Hells, to affect the oocyte maturation. Moreover, the translational landscape is profiled in human oocyte aging, and the similar translational changes of epigenetic modifications regulators between human and mice oocyte aging are observed. In particular, due to the translational silence of YTHDF3 in human oocytes, translation activity is not associated with m6A modification, but alternative splicing factor SRSF6. Together, the findings profile the specific translational landscapes during oocyte aging in mice and humans, and uncover non‐conservative regulators on translation control in meiosis resumption and maternal aging.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Multi‐Omics Analysis Reveals Translational Landscapes and Regulations in Mouse and Human Oocyte Aging ; day:03 ; month:07 ; year:2023 ; extent:20
Advanced science ; (03.07.2023) (gesamt 20)
- Creator
-
Huang, Jiana
Chen, Peigen
Jia, Lei
Li, Tingting
Yang, Xing
Liang, Qiqi
Zeng, Yanyan
Liu, Jiawen
Wu, Taibao
Hu, Wenqi
Kee, Kehkooi
Zeng, Haitao
Liang, Xiaoyan
Zhou, Chuanchuan
- DOI
-
10.1002/advs.202301538
- URN
-
urn:nbn:de:101:1-2023070415110636184979
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:45 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Huang, Jiana
- Chen, Peigen
- Jia, Lei
- Li, Tingting
- Yang, Xing
- Liang, Qiqi
- Zeng, Yanyan
- Liu, Jiawen
- Wu, Taibao
- Hu, Wenqi
- Kee, Kehkooi
- Zeng, Haitao
- Liang, Xiaoyan
- Zhou, Chuanchuan
Other Objects (12)
A 3–4 h oocyte retrieval-ICSI interval optimizes clinical outcomes for women over 40 years
BGFD: an integrated multi-omics database of barley gene families
Density expansions of extremes from general error distribution with applications
Autophagy-related biomarkers in hepatocellular carcinoma and their relationship with immune infiltration
Uncertainties in the national inventory of methane emissions from rice cultivation: field measurements and modeling approaches
Analytical comparison of absolute quantification strategies to investigate the Insulin signaling pathway in fat cells
Metabolic reprogramming and metabolic sensors in KSHV-induced cancers and KSHV infection
Characterization of kinase gene expression and splicing profile in prostate cancer with RNA-Seq data
A conjugate gradient algorithm and its application in large-scale optimization problems and image restoration
Effect of PCSK9 inhibitor on lipoprotein particles in patients with acute coronary syndromes
Pathophysiological role of calcium channels and transporters in the multiple myeloma
pKa determination of oxysophocarpine by reversed - phase high performance liquid chromatography
A 3–4 h oocyte retrieval-ICSI interval optimizes clinical outcomes for women over 40 years
BGFD: an integrated multi-omics database of barley gene families
Density expansions of extremes from general error distribution with applications
Autophagy-related biomarkers in hepatocellular carcinoma and their relationship with immune infiltration
Uncertainties in the national inventory of methane emissions from rice cultivation: field measurements and modeling approaches
Analytical comparison of absolute quantification strategies to investigate the Insulin signaling pathway in fat cells
Metabolic reprogramming and metabolic sensors in KSHV-induced cancers and KSHV infection
Characterization of kinase gene expression and splicing profile in prostate cancer with RNA-Seq data
A conjugate gradient algorithm and its application in large-scale optimization problems and image restoration
Effect of PCSK9 inhibitor on lipoprotein particles in patients with acute coronary syndromes
Pathophysiological role of calcium channels and transporters in the multiple myeloma
pKa determination of oxysophocarpine by reversed - phase high performance liquid chromatography
A 3–4 h oocyte retrieval-ICSI interval optimizes clinical outcomes for women over 40 years
BGFD: an integrated multi-omics database of barley gene families
Density expansions of extremes from general error distribution with applications
Autophagy-related biomarkers in hepatocellular carcinoma and their relationship with immune infiltration
Uncertainties in the national inventory of methane emissions from rice cultivation: field measurements and modeling approaches
Analytical comparison of absolute quantification strategies to investigate the Insulin signaling pathway in fat cells
Metabolic reprogramming and metabolic sensors in KSHV-induced cancers and KSHV infection
Characterization of kinase gene expression and splicing profile in prostate cancer with RNA-Seq data
A conjugate gradient algorithm and its application in large-scale optimization problems and image restoration
Effect of PCSK9 inhibitor on lipoprotein particles in patients with acute coronary syndromes
Pathophysiological role of calcium channels and transporters in the multiple myeloma