Multifunctional Antibacterial Nanonets Attenuate Inflammatory Responses through Selective Trapping of Endotoxins and Pro‐Inflammatory Cytokines
Abstract: Extracellular lipopolysaccharide (LPS) released from bacteria cells can enter the bloodstream and cause septic complications with excessive host inflammatory responses. Target‐specific strategies to inactivate inflammation mediators have largely failed to improve the prognosis of septic patients in clinical trials. By utilizing their high density of positive charges, de novo designed peptide nanonets are shown to selectively entrap the negatively charged LPS and pro‐inflammatory cytokines tumor necrosis factor‐α (TNF‐α) and interleukin‐6 (IL‐6). This in turn enables the nanonets to suppress LPS‐induced cytokine production by murine macrophage cell line and rescue the antimicrobial activity of the last‐resort antibiotic, colistin, from LPS binding. Using an acute lung injury model in mice, it is demonstrated that intratracheal administration of the fibrillating peptides is effective at lowering local release of TNF‐α and IL‐6. Together with previously shown ability to simultaneously trap and kill pathogenic bacteria, the peptide nanonets display remarkable potential as a holistic, multifunctional anti‐infective, and anti‐septic biomaterial.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Multifunctional Antibacterial Nanonets Attenuate Inflammatory Responses through Selective Trapping of Endotoxins and Pro‐Inflammatory Cytokines ; day:25 ; month:04 ; year:2023 ; extent:7
Advanced healthcare materials ; (25.04.2023) (gesamt 7)
- Creator
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Tram, Nhan Dai Thien
Tran, Quy Thi Ngoc
Xu, Jian
Su, Jeannie Ching Ting
Liao, Wupeng
Wong, Wai Shiu Fred
Ee, Pui Lai Rachel
- DOI
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10.1002/adhm.202203232
- URN
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urn:nbn:de:101:1-2023042615020960092188
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:52 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Tram, Nhan Dai Thien
- Tran, Quy Thi Ngoc
- Xu, Jian
- Su, Jeannie Ching Ting
- Liao, Wupeng
- Wong, Wai Shiu Fred
- Ee, Pui Lai Rachel
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