Bioengineering liver microtissues for modeling non-alcoholic fatty liver disease
Abstract: Non-alcoholic fatty liver disease (NAFLD) has become the world’s most common chronic liver disease. However, due to the lack of reliable in vitro NAFLD models, drug development studies have faced many limitations, and there is no food and drug administration-approved medicine for NAFLD treatment. A functional biomimetic in vitro human liver model requires an optimized natural microenvironment using appropriate cellular composition, to provide constructive cell-cell interactions, and niche-specific bio-molecules to supply crucial cues as cell-matrix interplay. Such a suitable liver model could employ appropriate and desired biochemical, mechanical, and physical properties similar to native tissue. Moreover, bioengineered three-dimensional tissues, specially microtissues and organoids, and more recently using infusion-based cultivation systems such as microfluidics can mimic natural tissue conditions and facilitate the exchange of nutrients and soluble factors to improve physiologica.... https://www.excli.de/excli/article/view/5892
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Bioengineering liver microtissues for modeling non-alcoholic fatty liver disease ; volume:22 ; year:2023
EXCLI journal ; 22 (2023)
- Creator
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Aasadollahei, Negar
Rezaei, Niloufar
Golroo, Reihaneh
Agarwal, Tarun
Vosough, Massoud
Piryaei, Abbas
- DOI
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10.17179/excli2023-5892
- URN
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urn:nbn:de:101:1-2502190900339.761369913169
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:32 AM CEST
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Aasadollahei, Negar
- Rezaei, Niloufar
- Golroo, Reihaneh
- Agarwal, Tarun
- Vosough, Massoud
- Piryaei, Abbas
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Correlation of non-alcoholic fatty liver disease and neurodegenerative disorders
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