Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D

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Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: 1 Online-Ressource.

Language: Englisch

Bibliographic citation: Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D ; day:5 ; month:3 ; year:2024 ; pages:1-9
Nature chemical biology ; (5.3.2024), 1-9

Creator: Zheng, Qinheng
Zhang, Ziyang
Guiley, Keelan Z.
Shokat, Kevan M.

Contributor: SpringerLink (Online service)

DOI: 10.1038/s41589-024-01565-w

URN: urn:nbn:de:101:1-2405070915503.783739835910

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:44 AM CEST

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Zheng, Qinheng
Zhang, Ziyang
Guiley, Keelan Z.
Shokat, Kevan M.
SpringerLink (Online service)

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Monitoring of RAS mutant clones in plasma of patients with RAS mutant metastatic colorectal cancer

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Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression

Biomimetic S-adenosylmethionine regeneration starting from multiple byproducts enables biocatalytic alkylation with radical sam enzymes

Biomimetic S ‐Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes **

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Monitoring of RAS mutant clones in plasma of patients with RAS mutant metastatic colorectal cancer

Funktionelle Charakterisierung von RAS-Mutanten im Rhabdomyosarkom

Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression

Biomimetic S-adenosylmethionine regeneration starting from multiple byproducts enables biocatalytic alkylation with radical sam enzymes

Biomimetic S ‐Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes **

Photochemical 1,3-boronate rearrangement enables three-component N-alkylation for α-tertiary hydroxybenzylamine synthesis

The effects of mutant Ras proteins on the cell signalome

RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax

Metal-free photocatalytic cross-electrophile coupling enables C1 homologation and alkylation of carboxylic acids with aldehydes

Structure-based inhibitor design of mutant RAS proteins—a paradigm shift

Dependence of NPPS creates a targetable vulnerability in RAS-mutant cancers

Mitochondrial inner membrane permeabilisation enables mt DNA release during apoptosis

Monitoring of RAS mutant clones in plasma of patients with RAS mutant metastatic colorectal cancer

Funktionelle Charakterisierung von RAS-Mutanten im Rhabdomyosarkom

Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression

Biomimetic S-adenosylmethionine regeneration starting from multiple byproducts enables biocatalytic alkylation with radical sam enzymes

Biomimetic S ‐Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes **

Photochemical 1,3-boronate rearrangement enables three-component N-alkylation for α-tertiary hydroxybenzylamine synthesis

The effects of mutant Ras proteins on the cell signalome

RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax

Metal-free photocatalytic cross-electrophile coupling enables C1 homologation and alkylation of carboxylic acids with aldehydes

Structure-based inhibitor design of mutant RAS proteins—a paradigm shift

Dependence of NPPS creates a targetable vulnerability in RAS-mutant cancers

Mitochondrial inner membrane permeabilisation enables mt DNA release during apoptosis

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Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D

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Other Objects (12)

Monitoring of RAS mutant clones in plasma of patients with RAS mutant metastatic colorectal cancer

Funktionelle Charakterisierung von RAS-Mutanten im Rhabdomyosarkom

Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression

Biomimetic S-adenosylmethionine regeneration starting from multiple byproducts enables biocatalytic alkylation with radical sam enzymes

Biomimetic S ‐Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes **

Photochemical 1,3-boronate rearrangement enables three-component N-alkylation for α-tertiary hydroxybenzylamine synthesis

The effects of mutant Ras proteins on the cell signalome

RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax

Metal-free photocatalytic cross-electrophile coupling enables C1 homologation and alkylation of carboxylic acids with aldehydes

Structure-based inhibitor design of mutant RAS proteins—a paradigm shift

Dependence of NPPS creates a targetable vulnerability in RAS-mutant cancers

Mitochondrial inner membrane permeabilisation enables mt DNA release during apoptosis

Monitoring of RAS mutant clones in plasma of patients with RAS mutant metastatic colorectal cancer

Funktionelle Charakterisierung von RAS-Mutanten im Rhabdomyosarkom

Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression

Biomimetic S-adenosylmethionine regeneration starting from multiple byproducts enables biocatalytic alkylation with radical sam enzymes

Biomimetic S ‐Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes **

Photochemical 1,3-boronate rearrangement enables three-component N-alkylation for α-tertiary hydroxybenzylamine synthesis

The effects of mutant Ras proteins on the cell signalome

RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax

Metal-free photocatalytic cross-electrophile coupling enables C1 homologation and alkylation of carboxylic acids with aldehydes

Structure-based inhibitor design of mutant RAS proteins—a paradigm shift

Dependence of NPPS creates a targetable vulnerability in RAS-mutant cancers

Mitochondrial inner membrane permeabilisation enables mt DNA release during apoptosis

Monitoring of RAS mutant clones in plasma of patients with RAS mutant metastatic colorectal cancer

Funktionelle Charakterisierung von RAS-Mutanten im Rhabdomyosarkom

Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression

Biomimetic S-adenosylmethionine regeneration starting from multiple byproducts enables biocatalytic alkylation with radical sam enzymes

Biomimetic S ‐Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes **

Photochemical 1,3-boronate rearrangement enables three-component N-alkylation for α-tertiary hydroxybenzylamine synthesis

The effects of mutant Ras proteins on the cell signalome

RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax

Metal-free photocatalytic cross-electrophile coupling enables C1 homologation and alkylation of carboxylic acids with aldehydes

Structure-based inhibitor design of mutant RAS proteins—a paradigm shift

Dependence of NPPS creates a targetable vulnerability in RAS-mutant cancers

Mitochondrial inner membrane permeabilisation enables mt DNA release during apoptosis

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