Mutualistic Synthesis from Orthogonal Dynamic Covalent Reactions
Abstract: Mutualisms are interactions that benefit all species involved. It has been widely investigated in neighbouring subjects, such as biology, ecology, sociology, and economics. However, such a reciprocal relationship in synthetic chemical systems has rarely been studied. Here, we demonstrate a mutualistic synthesis where byproducts from two orthogonal chemical reactions aid each other′s production. Disulfide exchange and hydrazone exchange were chosen to generate two dynamic combinatorial libraries. A minor tetrameric macrocycle from the active disulfide library was quantitatively amplified in the presence of the hydrazone library. This incorporation also turned on the previously inert hydrazone reaction, producing a linear species that formed a “handcuffs” catenane with the disulfide tetramer. These findings not only lend robust support to the hypothesis of “RNA‐peptide coevolution” for the origin of life but also broaden the scope of synthetic chemistry, highlighting the untapped potential of minor products from different reactions. Additionally, the co‐self‐assembly of these mutualistic entities to form supramolecular structures opens new avenues for future development of composite nanosystems with synergistic properties.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Mutualistic Synthesis from Orthogonal Dynamic Covalent Reactions ; volume:136 ; number:44 ; year:2024 ; extent:6
Angewandte Chemie ; 136, Heft 44 (2024) (gesamt 6)
- Creator
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Lyu, Yonglei
Hu, Ying
Yang, Jinghui
Wang, Xin
Li, Jianwei
- DOI
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10.1002/ange.202412020
- URN
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urn:nbn:de:101:1-2410181431339.751220701759
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:37 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Lyu, Yonglei
- Hu, Ying
- Yang, Jinghui
- Wang, Xin
- Li, Jianwei
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