Artificial Compartments Encapsulating Enzymatic Reactions: Towards the Construction of Artificial Organelles
Abstract: Cells have used compartmentalization to implement complex biological processes involving thousands of enzyme cascade reactions. Enzymes are spatially organized into the cellular compartments to carry out specific and efficient reactions in a spatiotemporally controlled manner. These compartments are divided into membrane‐bound and membraneless organelles. Mimicking such cellular compartment systems has been a challenge for years. A variety of artificial scaffolds, including liposomes, polymersomes, proteins, nucleic acids, or hybrid materials have been used to construct artificial membrane‐bound or membraneless compartments. These artificial compartments may have great potential for applications in biosynthesis, drug delivery, diagnosis and therapeutics, among others. This review first summarizes the typical examples of cellular compartments. In particular, the recent studies on cellular membraneless organelles (biomolecular condensates) are reviewed. We then summarize the recent advances in the construction of artificial compartments using engineered platforms. Finally, we provide our insights into the construction of biomimetic systems and the applications of these systems. This review article provides a timely summary of the relevant perspectives for the future development of artificial compartments, the building blocks for the construction of artificial organelles or cells.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Artificial Compartments Encapsulating Enzymatic Reactions: Towards the Construction of Artificial Organelles ; day:07 ; month:11 ; year:2024 ; extent:21
ChemPlusChem ; (07.11.2024) (gesamt 21)
- Creator
-
Lin, Peng
Zhang, Shiwei
Komatsubara, Futa
Konishi, Hiroaki
Nakata, Eiji
Morii, Takashi
- DOI
-
10.1002/cplu.202400483
- URN
-
urn:nbn:de:101:1-2411081402587.225623688344
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:24 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Lin, Peng
- Zhang, Shiwei
- Komatsubara, Futa
- Konishi, Hiroaki
- Nakata, Eiji
- Morii, Takashi
Other Objects (12)
An Artificial Liposome Compartment with Size Exclusion Molecular Transport
Numerical Investigation on the Strain Evolution of Ti-6Al-4V Alloy during Multi-directional Forging at Elevated Temperatures
Tunable Phase Distribution of Liquid Metamaterial
Fact Checking in Knowledge Graphs with Ontological Subgraph Patterns
Artificial Organelles: Towards Adding or Restoring Intracellular Activity
Effect of architectural adjustments on pedestrian flow at bottleneck
A Practical Approach for Polarity and Quantity Controlled Assembly of Membrane Proteins into Nanoliposomes
Increased serum asprosin is correlated with diabetic nephropathy
Dynamic Assembly of Cascade Enzymes by the Shape Transformation of a DNA Scaffold
Functional nanocarriers as compartments for artificial cells
Different pH-responsive polymersomes as artificial organelles and subcompartments of novel artificial cells
Dipeptide coacervates as artificial membraneless organelles for bioorthogonal catalysis
An Artificial Liposome Compartment with Size Exclusion Molecular Transport
Numerical Investigation on the Strain Evolution of Ti-6Al-4V Alloy during Multi-directional Forging at Elevated Temperatures
Tunable Phase Distribution of Liquid Metamaterial
Fact Checking in Knowledge Graphs with Ontological Subgraph Patterns
Artificial Organelles: Towards Adding or Restoring Intracellular Activity
Effect of architectural adjustments on pedestrian flow at bottleneck
A Practical Approach for Polarity and Quantity Controlled Assembly of Membrane Proteins into Nanoliposomes
Increased serum asprosin is correlated with diabetic nephropathy
Dynamic Assembly of Cascade Enzymes by the Shape Transformation of a DNA Scaffold
Functional nanocarriers as compartments for artificial cells
Different pH-responsive polymersomes as artificial organelles and subcompartments of novel artificial cells
Dipeptide coacervates as artificial membraneless organelles for bioorthogonal catalysis
An Artificial Liposome Compartment with Size Exclusion Molecular Transport
Numerical Investigation on the Strain Evolution of Ti-6Al-4V Alloy during Multi-directional Forging at Elevated Temperatures
Tunable Phase Distribution of Liquid Metamaterial
Fact Checking in Knowledge Graphs with Ontological Subgraph Patterns
Artificial Organelles: Towards Adding or Restoring Intracellular Activity
Effect of architectural adjustments on pedestrian flow at bottleneck
A Practical Approach for Polarity and Quantity Controlled Assembly of Membrane Proteins into Nanoliposomes
Increased serum asprosin is correlated with diabetic nephropathy
Dynamic Assembly of Cascade Enzymes by the Shape Transformation of a DNA Scaffold
Functional nanocarriers as compartments for artificial cells
Different pH-responsive polymersomes as artificial organelles and subcompartments of novel artificial cells