Targeting tRNA‐Derived Non‐Coding RNA Alleviates Diabetes‐Induced Visual Impairment through Protecting Retinal Neurovascular Unit
Abstract: Diabetes is a major risk factor for compromised visual health, leading to retinal vasculopathy and neuropathy, both of which are hallmarks of neurovascular unit dysfunction. Despite the critical impact of diabetic retinopathy, the precise mechanism underlying neurovascular coupling and effective strategies to suppress neurovascular dysfunction remain unclear. In this study, the up‐regulation of a tRNA‐derived stress‐induced RNA, 5′tiRNA‐His‐GTG, in response to diabetic stress is revealed. 5′tiRNA‐His‐GTG directly regulates Müller glia action and indirectly alters endothelial angiogenic effects and retinal ganglion cell (RGC) survival in vitro. Downregulation of 5′tiRNA‐His‐GTG alleviates diabetes‐induced retinal neurovascular dysfunction, characterized by reduced retinal vascular dysfunction, decreased retinal neurodegeneration, and improved visually‐guided behaviors in vivo. Mechanistically, 5′tiRNA‐His‐GTG acts as a key regulator of retinal neurovascular dysfunction, primarily by modulating arachidonic acid (AA) metabolism via the CYPs pathway. The 5′tiRNA‐His‐GTG‐CYP2E1‐19 (S)‐HETE signaling axis is identified as a key driver of retinal neurovascular dysfunction. Thus, targeting 5′tiRNA‐His‐GTG presents a promising therapeutic strategy for treating vasculopathy and neuropathy associated with diabetes mellitus. Modulating this novel signaling pathway can open up new avenues for intervention in diabetic retinopathy and its related complications.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Targeting tRNA‐Derived Non‐Coding RNA Alleviates Diabetes‐Induced Visual Impairment through Protecting Retinal Neurovascular Unit ; day:08 ; month:11 ; year:2024 ; extent:15
Advanced science ; (08.11.2024) (gesamt 15)
- Creator
-
Yao, Jin
Yao, Wen
Zhu, Jun‐Ya
Liu, Yan
Liu, Jin‐Hong
Ji, Yu‐Ke
Ni, Xi‐Shen
Mu, Wan
Yan, Biao
- DOI
-
10.1002/advs.202411042
- URN
-
urn:nbn:de:101:1-2411091351152.313729125253
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:36 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Yao, Jin
- Yao, Wen
- Zhu, Jun‐Ya
- Liu, Yan
- Liu, Jin‐Hong
- Ji, Yu‐Ke
- Ni, Xi‐Shen
- Mu, Wan
- Yan, Biao
Other Objects (12)
Li dai di li yan ge tu
Readability and adaptation of children’s literature: an interpersonal metaphor perspective
Readability and adaptation of children’s literary works from the perspective of ideational grammatical metaphor
A novel cardio-oncology service line model in optimizing care access, quality and equity for large, multi-hospital health systems
Acceleration and Deceleration Behavior of Skyrmion Controlled by Curvature Gradient in Elliptical‐Ring Track
A novel endoloop pretest to treat severe gastroesophageal reflux disease symptoms before anti-reflux mucosectomy
A Bi-GRU-DSA-based social network rumor detection approach
Spatially homogeneous Lifshitz black holes in five dimensional higher derivative gravity
The relationship and heterogeneity of family participation and social participation among older adults: from an intersectionality perspective
lncRNA–disease association prediction method based on the nearest neighbor matrix completion model
Identification and characterization of CircRNA-associated CeRNA networks in moso bamboo under nitrogen stress
Bridging heterogeneous and homogeneous catalysis : concepts, strategies, and applications
Li dai di li yan ge tu
Readability and adaptation of children’s literature: an interpersonal metaphor perspective
Readability and adaptation of children’s literary works from the perspective of ideational grammatical metaphor
A novel cardio-oncology service line model in optimizing care access, quality and equity for large, multi-hospital health systems
Acceleration and Deceleration Behavior of Skyrmion Controlled by Curvature Gradient in Elliptical‐Ring Track
A novel endoloop pretest to treat severe gastroesophageal reflux disease symptoms before anti-reflux mucosectomy
A Bi-GRU-DSA-based social network rumor detection approach
Spatially homogeneous Lifshitz black holes in five dimensional higher derivative gravity
The relationship and heterogeneity of family participation and social participation among older adults: from an intersectionality perspective
lncRNA–disease association prediction method based on the nearest neighbor matrix completion model
Identification and characterization of CircRNA-associated CeRNA networks in moso bamboo under nitrogen stress
Bridging heterogeneous and homogeneous catalysis : concepts, strategies, and applications
Li dai di li yan ge tu
Readability and adaptation of children’s literature: an interpersonal metaphor perspective
Readability and adaptation of children’s literary works from the perspective of ideational grammatical metaphor
A novel cardio-oncology service line model in optimizing care access, quality and equity for large, multi-hospital health systems
Acceleration and Deceleration Behavior of Skyrmion Controlled by Curvature Gradient in Elliptical‐Ring Track
A novel endoloop pretest to treat severe gastroesophageal reflux disease symptoms before anti-reflux mucosectomy
A Bi-GRU-DSA-based social network rumor detection approach
Spatially homogeneous Lifshitz black holes in five dimensional higher derivative gravity
The relationship and heterogeneity of family participation and social participation among older adults: from an intersectionality perspective
lncRNA–disease association prediction method based on the nearest neighbor matrix completion model
Identification and characterization of CircRNA-associated CeRNA networks in moso bamboo under nitrogen stress