miR-539 mediates osteoblast mineralization by regulating Distal-less genes 2 in MC3T3-E1 cell line
Abstract: microRNAs (miRNAs) play an important role in osteoblast differentiation. However, the mechanisms of miRNAs regulating osteoblast mineralization still needs to be further cleared. Distal-less genes 2 (Dlx2) plays an important role in osteoblast differentiation. We have found that miR-539 was significantly downregulated and Dlx2 was found to be inversely correlated with miR-539 in MC3T3-E1 cell line during osteoblast mineralization. The overexpression of miR-539 significantly decreased the expression level of Dlx2 and suppressed the osteogenic marker gene expression level, alkaline phosphatase activity and matrix mineralization. Our study showed that miR-539 was a negative regulator in osteoblast mineralization and that the targeting of Dlx2 gene partly contributes to this inhibitory effect exerted by miR-539.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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miR-539 mediates osteoblast mineralization by regulating Distal-less genes 2 in MC3T3-E1 cell line ; volume:12 ; number:1 ; year:2017 ; pages:294-299 ; extent:6
Open life sciences ; 12, Heft 1 (2017), 294-299 (gesamt 6)
- Creator
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Han, Jianguo
Su, Li
Zhang, Chunyang
Jiang, Rongcai
- DOI
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10.1515/biol-2017-0034
- URN
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urn:nbn:de:101:1-2409201642440.021323152479
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:22 AM CEST
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Associated
- Han, Jianguo
- Su, Li
- Zhang, Chunyang
- Jiang, Rongcai
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